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Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

BACKGROUND: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mutations of IDH1 and IDH2 have recently been reported in some types of brain tumors and a small pro...

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Detalles Bibliográficos
Autores principales:	Chotirat, Sadudee, Thongnoppakhun, Wanna, Promsuwicha, Orathai, Boonthimat, Chetsada, Auewarakul, Chirayu U
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320529/ https://www.ncbi.nlm.nih.gov/pubmed/22397365 http://dx.doi.org/10.1186/1756-8722-5-5

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