Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines

In higher eukaryotes, replication program specification in different cell types remains to be fully understood. We show for seven human cell lines that about half of the genome is divided in domains that display a characteristic U-shaped replication timing profile with early initiation zones at bord...

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Detalles Bibliográficos
Autores principales: Baker, Antoine, Audit, Benjamin, Chen, Chun-Long, Moindrot, Benoit, Leleu, Antoine, Guilbaud, Guillaume, Rappailles, Aurélien, Vaillant, Cédric, Goldar, Arach, Mongelard, Fabien, d'Aubenton-Carafa, Yves, Hyrien, Olivier, Thermes, Claude, Arneodo, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320577/
https://www.ncbi.nlm.nih.gov/pubmed/22496629
http://dx.doi.org/10.1371/journal.pcbi.1002443

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