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Small-Molecule Inhibitors of Dengue-Virus Entry
Flavivirus envelope protein (E) mediates membrane fusion and viral entry from endosomes. A low-pH induced, dimer-to-trimer rearrangement and reconfiguration of the membrane-proximal “stem" of the E ectodomain draw together the viral and cellular membranes. We found stem-derived peptides from de...
Autores principales: | Schmidt, Aaron G., Lee, Kyungae, Yang, Priscilla L., Harrison, Stephen C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320583/ https://www.ncbi.nlm.nih.gov/pubmed/22496653 http://dx.doi.org/10.1371/journal.ppat.1002627 |
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