Cargando…

Leishmania Induces Survival, Proliferation and Elevated Cellular dNTP Levels in Human Monocytes Promoting Acceleration of HIV Co-Infection

Leishmaniasis is a parasitic disease that is widely prevalent in many tropical and sub-tropical regions of the world. Infection with Leishmania has been recognized to induce a striking acceleration of Human Immunodeficiency Virus Type 1 (HIV-1) infection in coinfected individuals through as yet inco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mock, David J., Hollenbaugh, Joseph A., Daddacha, Waaqo, Overstreet, Michael G., Lazarski, Chris A., Fowell, Deborah J., Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320607/ https://www.ncbi.nlm.nih.gov/pubmed/22496656 http://dx.doi.org/10.1371/journal.ppat.1002635

Ejemplares similares

dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
por: Hollenbaugh, Joseph A, et al.
Publicado: (2014)

A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei
por: Antequera-Parrilla, Pablo, et al.
Publicado: (2023)

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
por: Schmidt, Tobias T, et al.
Publicado: (2019)

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
por: Kumar, Dinesh, et al.
Publicado: (2011)

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants
por: Fasullo, Michael, et al.
Publicado: (2010)

Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages
por: Bowen, Nicole E., et al.
Publicado: (2023)

Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages
por: Shepard, Caitlin, et al.
Publicado: (2019)

Reciprocal regulation of autophagy and dNTP pools in human cancer cells
por: Chen, Wei, et al.
Publicado: (2014)

Suppression of the E. coli SOS response by dNTP pool changes
por: Maslowska, Katarzyna H., et al.
Publicado: (2015)

Fatty acid carbon is essential for dNTP synthesis in endothelial cells
por: Schoors, Sandra, et al.
Publicado: (2015)

Catalytic properties of RNA polymerases IV and V: accuracy, nucleotide incorporation and rNTP/dNTP discrimination
por: Marasco, Michelle, et al.
Publicado: (2017)

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4(+) T-lymphocytes cannot be upregulated by interferons
por: St Gelais, Corine, et al.
Publicado: (2012)

Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs
por: Petrie, Katherine L., et al.
Publicado: (2010)

dNTP Supply Gene Expression Patterns after P53 Loss
por: Radivoyevitch, Tomas, et al.
Publicado: (2012)

Characterization of purple acid phosphatases involved in extracellular dNTP utilization in Stylosanthes
por: Liu, Pan-Dao, et al.
Publicado: (2016)

An essential role for dNTP homeostasis following CDK-induced replication stress
por: Pai, Chen-Chun, et al.
Publicado: (2019)

The effects of mycobacterial RmlA perturbation on cellular dNTP pool, cell morphology, and replication stress in Mycobacterium smegmatis
por: Hirmondó, Rita, et al.
Publicado: (2022)

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion
por: Giannattasio, Michele, et al.
Publicado: (2017)

Chl1 helicase controls replication fork progression by regulating dNTP pools
por: Batté, Amandine, et al.
Publicado: (2022)

UV induced ubiquitination of the yeast Rad4–Rad23 complex promotes survival by regulating cellular dNTP pools
por: Zhou, Zheng, et al.
Publicado: (2015)

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels
por: Rocha-Perugini, Vera, et al.
Publicado: (2017)

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
por: Kumar, Dinesh, et al.
Publicado: (2010)

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools
por: Tsaponina, Olga, et al.
Publicado: (2011)

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools
por: Watt, Danielle L., et al.
Publicado: (2016)

Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes
por: Hirmondo, Rita, et al.
Publicado: (2017)

Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
por: Harada, Yoichiro, et al.
Publicado: (2023)

Mismatched and Matched dNTP Incorporation by DNA Polymerase β Proceed via Analogous Kinetic Pathways
por: Roettger, Michelle P., et al.
Publicado: (2008)

S phase block following MEC1(ATR) inactivation occurs without severe dNTP depletion
por: Earp, Caroline, et al.
Publicado: (2015)

Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity
por: Buckland, Robert J., et al.
Publicado: (2014)

Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells
por: Qu, Jia, et al.
Publicado: (2017)

The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
por: Tramentozzi, Elisa, et al.
Publicado: (2018)

ERK Inhibitor Enhances Everolimus Efficacy through the Attenuation of dNTP Pools in Renal Cell Carcinoma
por: Zou, Yun, et al.
Publicado: (2019)

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis
por: Morris, Elizabeth R., et al.
Publicado: (2020)

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools
por: Kychygina, Anna, et al.
Publicado: (2021)

Loss of Yeast Peroxiredoxin Tsa1p Induces Genome Instability through Activation of the DNA Damage Checkpoint and Elevation of dNTP Levels
por: Tang, Hei-Man Vincent, et al.
Publicado: (2009)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells
por: Qu, Jia, et al.
Publicado: (2017)

RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools
por: Meroni, Alice, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n6fr3i6ujmd4s12mpoum8i3bjc