Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses

The development of an effective malaria vaccine is a high global health priority. Vaccine vectors based on adenovirus type 5 are capable of generating robust and protective T cell and antibody responses in animal models and are currently being evaluated in clinical trials for HIV and malaria. They a...

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Detalles Bibliográficos
Autores principales: Bruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L., Doolan, Denise L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320611/
https://www.ncbi.nlm.nih.gov/pubmed/22496772
http://dx.doi.org/10.1371/journal.pone.0033920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320611/
https://www.ncbi.nlm.nih.gov/pubmed/22496772
http://dx.doi.org/10.1371/journal.pone.0033920

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