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Analysis of Polymorphisms and Haplotype Structure of the Human Thymidylate Synthase Genetic Region: A Tool for Pharmacogenetic Studies

5-fluorouracil (5FU), a widely used chemotherapeutic drug, inhibits the DNA replicative enzyme, thymidylate synthase (Tyms). Prior studies implicated a VNTR (variable numbers of tandem repeats) polymorphism in the 5′-untranslated region (5′-UTR) of the TYMS gene as a determinant of Tyms expression i...

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Detalles Bibliográficos
Autores principales:	Ghosh, Soma, Hossain, M. Zulfiquer, Borges, Michael, Goggins, Michael G., Ingersoll, Roxann G., Eshleman, James R., Klein, Alison P., Kern, Scott E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320636/ https://www.ncbi.nlm.nih.gov/pubmed/22496803 http://dx.doi.org/10.1371/journal.pone.0034426

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