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Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT

BACKGROUND: The immune system exerts a diversifying selection pressure on HIV through cellular, humoral and innate mechanisms. This pressure drives viral evolution throughout infection. A better understanding of the natural immune pressure on the virus during infection is warranted, given the clinic...

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Autores principales: Van den Bergh, Rafael, Morin, Sébastien, Sass, Hans Jürgen, Grzesiek, Stephan, Vekemans, Marc, Florence, Eric, Thanh Thi Tran, Huyen, Imiru, Rosina Gabriel, Heyndrickx, Leo, Vanham, Guido, De Baetselier, Patrick, Raes, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320877/
https://www.ncbi.nlm.nih.gov/pubmed/22493731
http://dx.doi.org/10.1371/journal.pone.0035074
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author Van den Bergh, Rafael
Morin, Sébastien
Sass, Hans Jürgen
Grzesiek, Stephan
Vekemans, Marc
Florence, Eric
Thanh Thi Tran, Huyen
Imiru, Rosina Gabriel
Heyndrickx, Leo
Vanham, Guido
De Baetselier, Patrick
Raes, Geert
author_facet Van den Bergh, Rafael
Morin, Sébastien
Sass, Hans Jürgen
Grzesiek, Stephan
Vekemans, Marc
Florence, Eric
Thanh Thi Tran, Huyen
Imiru, Rosina Gabriel
Heyndrickx, Leo
Vanham, Guido
De Baetselier, Patrick
Raes, Geert
author_sort Van den Bergh, Rafael
collection PubMed
description BACKGROUND: The immune system exerts a diversifying selection pressure on HIV through cellular, humoral and innate mechanisms. This pressure drives viral evolution throughout infection. A better understanding of the natural immune pressure on the virus during infection is warranted, given the clinical interest in eliciting and sustaining an immune response to HIV which can help to control the infection. We undertook to evaluate the potential of the novel HIV-induced, monocyte-derived factor visfatin to modulate viral infection, as part of the innate immune pressure on viral populations. RESULTS: We show that visfatin is capable of selectively inhibiting infection by R5 HIV strains in macrophages and resting PBMC in vitro, while at the same time remaining indifferent to or even favouring infection by X4 strains. Furthermore, visfatin exerts a direct effect on the relative fitness of R5 versus X4 infections in a viral competition setup. Direct interaction of visfatin with the CCR5 receptor is proposed as a putative mechanism for this differential effect. Possible in vivo relevance of visfatin induction is illustrated by its association with the dominance of CXCR4-using HIV in the plasma. CONCLUSIONS: As an innate factor produced by monocytes, visfatin is capable of inhibiting infections by R5 but not X4 strains, reflecting a potential selective pressure against R5 viruses.
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spelling pubmed-33208772012-04-10 Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT Van den Bergh, Rafael Morin, Sébastien Sass, Hans Jürgen Grzesiek, Stephan Vekemans, Marc Florence, Eric Thanh Thi Tran, Huyen Imiru, Rosina Gabriel Heyndrickx, Leo Vanham, Guido De Baetselier, Patrick Raes, Geert PLoS One Research Article BACKGROUND: The immune system exerts a diversifying selection pressure on HIV through cellular, humoral and innate mechanisms. This pressure drives viral evolution throughout infection. A better understanding of the natural immune pressure on the virus during infection is warranted, given the clinical interest in eliciting and sustaining an immune response to HIV which can help to control the infection. We undertook to evaluate the potential of the novel HIV-induced, monocyte-derived factor visfatin to modulate viral infection, as part of the innate immune pressure on viral populations. RESULTS: We show that visfatin is capable of selectively inhibiting infection by R5 HIV strains in macrophages and resting PBMC in vitro, while at the same time remaining indifferent to or even favouring infection by X4 strains. Furthermore, visfatin exerts a direct effect on the relative fitness of R5 versus X4 infections in a viral competition setup. Direct interaction of visfatin with the CCR5 receptor is proposed as a putative mechanism for this differential effect. Possible in vivo relevance of visfatin induction is illustrated by its association with the dominance of CXCR4-using HIV in the plasma. CONCLUSIONS: As an innate factor produced by monocytes, visfatin is capable of inhibiting infections by R5 but not X4 strains, reflecting a potential selective pressure against R5 viruses. Public Library of Science 2012-04-06 /pmc/articles/PMC3320877/ /pubmed/22493731 http://dx.doi.org/10.1371/journal.pone.0035074 Text en Van den Bergh et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Van den Bergh, Rafael
Morin, Sébastien
Sass, Hans Jürgen
Grzesiek, Stephan
Vekemans, Marc
Florence, Eric
Thanh Thi Tran, Huyen
Imiru, Rosina Gabriel
Heyndrickx, Leo
Vanham, Guido
De Baetselier, Patrick
Raes, Geert
Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT
title Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT
title_full Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT
title_fullStr Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT
title_full_unstemmed Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT
title_short Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT
title_sort monocytes contribute to differential immune pressure on r5 versus x4 hiv through the adipocytokine visfatin/nampt
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320877/
https://www.ncbi.nlm.nih.gov/pubmed/22493731
http://dx.doi.org/10.1371/journal.pone.0035074
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