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Mutation Accumulation May Be a Minor Force in Shaping Life History Traits

Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-stri...

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Autores principales: Dańko, Maciej Jan, Kozłowski, Jan, Vaupel, James Walton, Baudisch, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320907/
https://www.ncbi.nlm.nih.gov/pubmed/22493680
http://dx.doi.org/10.1371/journal.pone.0034146
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author Dańko, Maciej Jan
Kozłowski, Jan
Vaupel, James Walton
Baudisch, Annette
author_facet Dańko, Maciej Jan
Kozłowski, Jan
Vaupel, James Walton
Baudisch, Annette
author_sort Dańko, Maciej Jan
collection PubMed
description Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-strings to capture different age-specific mutational patterns. Each pattern represents a genotype and for each genotype we find the life history strategy that maximizes fitness. Genotypes compete with each other and are subject to selection and to new mutations over generations until equilibrium in gene-frequencies is reached. The mutation-selection equilibrium provides information about mutational load and the differential effects of mutations on a life history trait - the optimal age at maturity. We find that mutations accumulate only at ages with negligible impact on fitness and that mutation accumulation has very little effect on the optimal age at maturity. These results suggest that life histories are largely determined by adaptive processes. The non-adaptive process of mutation accumulation seems to be unimportant at evolutionarily relevant ages.
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spelling pubmed-33209072012-04-10 Mutation Accumulation May Be a Minor Force in Shaping Life History Traits Dańko, Maciej Jan Kozłowski, Jan Vaupel, James Walton Baudisch, Annette PLoS One Research Article Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-strings to capture different age-specific mutational patterns. Each pattern represents a genotype and for each genotype we find the life history strategy that maximizes fitness. Genotypes compete with each other and are subject to selection and to new mutations over generations until equilibrium in gene-frequencies is reached. The mutation-selection equilibrium provides information about mutational load and the differential effects of mutations on a life history trait - the optimal age at maturity. We find that mutations accumulate only at ages with negligible impact on fitness and that mutation accumulation has very little effect on the optimal age at maturity. These results suggest that life histories are largely determined by adaptive processes. The non-adaptive process of mutation accumulation seems to be unimportant at evolutionarily relevant ages. Public Library of Science 2012-04-06 /pmc/articles/PMC3320907/ /pubmed/22493680 http://dx.doi.org/10.1371/journal.pone.0034146 Text en Dańko et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dańko, Maciej Jan
Kozłowski, Jan
Vaupel, James Walton
Baudisch, Annette
Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
title Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
title_full Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
title_fullStr Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
title_full_unstemmed Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
title_short Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
title_sort mutation accumulation may be a minor force in shaping life history traits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320907/
https://www.ncbi.nlm.nih.gov/pubmed/22493680
http://dx.doi.org/10.1371/journal.pone.0034146
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