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Cholesterol Depletion in Adipocytes Causes Caveolae Collapse Concomitant with Proteosomal Degradation of Cavin-2 in a Switch-Like Fashion

Caveolae, little caves of cell surfaces, are enriched in cholesterol, a certain level of which is required for their structural integrity. Here we show in adipocytes that cavin-2, a peripheral membrane protein and one of 3 cavin isoforms present in caveolae from non-muscle tissue, is degraded upon c...

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Detalles Bibliográficos
Autores principales: Breen, Michael R., Camps, Marta, Carvalho-Simoes, Francisco, Zorzano, Antonio, Pilch, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321009/
https://www.ncbi.nlm.nih.gov/pubmed/22493697
http://dx.doi.org/10.1371/journal.pone.0034516

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