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Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps f...

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Detalles Bibliográficos
Autores principales:	Machado, Diana, Couto, Isabel, Perdigão, João, Rodrigues, Liliana, Portugal, Isabel, Baptista, Pedro, Veigas, Bruno, Amaral, Leonard, Viveiros, Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321020/ https://www.ncbi.nlm.nih.gov/pubmed/22493700 http://dx.doi.org/10.1371/journal.pone.0034538

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