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A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

The G protein-coupled receptor (GPCR) Proteolysis Site (GPS) of cell-adhesion GPCRs and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis sequence, but its catalytic mechanism remains unknown. Here, we show that unexpectedly the ∼40-residue GPS motif represents...

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Detalles Bibliográficos
Autores principales:	Araç, Demet, Boucard, Antony A, Bolliger, Marc F, Nguyen, Jenna, Soltis, S Michael, Südhof, Thomas C, Brunger, Axel T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Molecular Biology Organization 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321182/ https://www.ncbi.nlm.nih.gov/pubmed/22333914 http://dx.doi.org/10.1038/emboj.2012.26

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