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Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses
Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinoph...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321291/ https://www.ncbi.nlm.nih.gov/pubmed/22536544 http://dx.doi.org/10.1155/2012/512097 |
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author | Morassutti, Alessandra L. Graeff-Teixeira, Carlos |
author_facet | Morassutti, Alessandra L. Graeff-Teixeira, Carlos |
author_sort | Morassutti, Alessandra L. |
collection | PubMed |
description | Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). In this paper we discuss the role of ES proteins on disease exacerbation and their potential use as therapeutic targets. |
format | Online Article Text |
id | pubmed-3321291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33212912012-04-25 Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses Morassutti, Alessandra L. Graeff-Teixeira, Carlos Int J Inflam Review Article Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). In this paper we discuss the role of ES proteins on disease exacerbation and their potential use as therapeutic targets. Hindawi Publishing Corporation 2012 2012-03-26 /pmc/articles/PMC3321291/ /pubmed/22536544 http://dx.doi.org/10.1155/2012/512097 Text en Copyright © 2012 A. L. Morassutti and C. Graeff-Teixeira. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Morassutti, Alessandra L. Graeff-Teixeira, Carlos Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
title | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
title_full | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
title_fullStr | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
title_full_unstemmed | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
title_short | Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses |
title_sort | interface molecules of angiostrongylus cantonensis: their role in parasite survival and modulation of host defenses |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321291/ https://www.ncbi.nlm.nih.gov/pubmed/22536544 http://dx.doi.org/10.1155/2012/512097 |
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