Cargando…

Regulatory T Cells in Type 1 Autoimmune Pancreatitis

Autoimmune pancreatitis (AIP) is a newly recognized pancreatic disorder. Recently, International Consensus Diagnostic Criteria for AIP (ICDC) was published. In this ICDC, AIP was classified into Type 1 and Type 2. Patients with Type 1 AIP have several immunologic and histologic abnormalities specifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Uchida, Kazushige, Kusuda, Takeo, Koyabu, Masanori, Miyoshi, Hideaki, Fukata, Norimasa, Sumimoto, Kimi, Fukui, Yuri, Sakaguchi, Yutaku, Ikeura, Tsukasa, Shimatani, Masaaki, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, Nishio, Akiyoshi, Okazaki, Kazuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321297/
https://www.ncbi.nlm.nih.gov/pubmed/22536257
http://dx.doi.org/10.1155/2012/795026
_version_ 1782228931037888512
author Uchida, Kazushige
Kusuda, Takeo
Koyabu, Masanori
Miyoshi, Hideaki
Fukata, Norimasa
Sumimoto, Kimi
Fukui, Yuri
Sakaguchi, Yutaku
Ikeura, Tsukasa
Shimatani, Masaaki
Fukui, Toshiro
Matsushita, Mitsunobu
Takaoka, Makoto
Nishio, Akiyoshi
Okazaki, Kazuichi
author_facet Uchida, Kazushige
Kusuda, Takeo
Koyabu, Masanori
Miyoshi, Hideaki
Fukata, Norimasa
Sumimoto, Kimi
Fukui, Yuri
Sakaguchi, Yutaku
Ikeura, Tsukasa
Shimatani, Masaaki
Fukui, Toshiro
Matsushita, Mitsunobu
Takaoka, Makoto
Nishio, Akiyoshi
Okazaki, Kazuichi
author_sort Uchida, Kazushige
collection PubMed
description Autoimmune pancreatitis (AIP) is a newly recognized pancreatic disorder. Recently, International Consensus Diagnostic Criteria for AIP (ICDC) was published. In this ICDC, AIP was classified into Type 1 and Type 2. Patients with Type 1 AIP have several immunologic and histologic abnormalities specific to the disease, including increased levels of serum IgG4 and storiform fibrosis with infiltration of lymphocytes and IgG4-positive plasmacytes in the involved organs. Among the involved organs showing extrapancreatic lesions, the bile duct is the most common, exhibiting sclerosing cholangitis (IgG4-SC). However, the role of IgG4 is unclear. Recently, it has been reported that regulatory T cells (Tregs) are involved in both the development of various autoimmune diseases and the shift of B cells toward IgG4, producing plasmacytes. Our study showed that Tregs were increased in the pancreas with Type 1 AIP and IgG4-SC compared with control. In the patients with Type 1 AIP and IgG4-SC, the numbers of infiltrated Tregs were significantly positively correlated with IgG4-positive plasma cells. In Type 1 AIP, inducible costimulatory molecule (ICOS)(+) and IL-10(+) Tregs significantly increased compared with control groups. Our data suggest that increased quantities of ICOS(+) Tregs may influence IgG4 production via IL-10 in Type 1 AIP.
format Online
Article
Text
id pubmed-3321297
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33212972012-04-25 Regulatory T Cells in Type 1 Autoimmune Pancreatitis Uchida, Kazushige Kusuda, Takeo Koyabu, Masanori Miyoshi, Hideaki Fukata, Norimasa Sumimoto, Kimi Fukui, Yuri Sakaguchi, Yutaku Ikeura, Tsukasa Shimatani, Masaaki Fukui, Toshiro Matsushita, Mitsunobu Takaoka, Makoto Nishio, Akiyoshi Okazaki, Kazuichi Int J Rheumatol Review Article Autoimmune pancreatitis (AIP) is a newly recognized pancreatic disorder. Recently, International Consensus Diagnostic Criteria for AIP (ICDC) was published. In this ICDC, AIP was classified into Type 1 and Type 2. Patients with Type 1 AIP have several immunologic and histologic abnormalities specific to the disease, including increased levels of serum IgG4 and storiform fibrosis with infiltration of lymphocytes and IgG4-positive plasmacytes in the involved organs. Among the involved organs showing extrapancreatic lesions, the bile duct is the most common, exhibiting sclerosing cholangitis (IgG4-SC). However, the role of IgG4 is unclear. Recently, it has been reported that regulatory T cells (Tregs) are involved in both the development of various autoimmune diseases and the shift of B cells toward IgG4, producing plasmacytes. Our study showed that Tregs were increased in the pancreas with Type 1 AIP and IgG4-SC compared with control. In the patients with Type 1 AIP and IgG4-SC, the numbers of infiltrated Tregs were significantly positively correlated with IgG4-positive plasma cells. In Type 1 AIP, inducible costimulatory molecule (ICOS)(+) and IL-10(+) Tregs significantly increased compared with control groups. Our data suggest that increased quantities of ICOS(+) Tregs may influence IgG4 production via IL-10 in Type 1 AIP. Hindawi Publishing Corporation 2012 2012-03-28 /pmc/articles/PMC3321297/ /pubmed/22536257 http://dx.doi.org/10.1155/2012/795026 Text en Copyright © 2012 Kazushige Uchida et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Uchida, Kazushige
Kusuda, Takeo
Koyabu, Masanori
Miyoshi, Hideaki
Fukata, Norimasa
Sumimoto, Kimi
Fukui, Yuri
Sakaguchi, Yutaku
Ikeura, Tsukasa
Shimatani, Masaaki
Fukui, Toshiro
Matsushita, Mitsunobu
Takaoka, Makoto
Nishio, Akiyoshi
Okazaki, Kazuichi
Regulatory T Cells in Type 1 Autoimmune Pancreatitis
title Regulatory T Cells in Type 1 Autoimmune Pancreatitis
title_full Regulatory T Cells in Type 1 Autoimmune Pancreatitis
title_fullStr Regulatory T Cells in Type 1 Autoimmune Pancreatitis
title_full_unstemmed Regulatory T Cells in Type 1 Autoimmune Pancreatitis
title_short Regulatory T Cells in Type 1 Autoimmune Pancreatitis
title_sort regulatory t cells in type 1 autoimmune pancreatitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321297/
https://www.ncbi.nlm.nih.gov/pubmed/22536257
http://dx.doi.org/10.1155/2012/795026
work_keys_str_mv AT uchidakazushige regulatorytcellsintype1autoimmunepancreatitis
AT kusudatakeo regulatorytcellsintype1autoimmunepancreatitis
AT koyabumasanori regulatorytcellsintype1autoimmunepancreatitis
AT miyoshihideaki regulatorytcellsintype1autoimmunepancreatitis
AT fukatanorimasa regulatorytcellsintype1autoimmunepancreatitis
AT sumimotokimi regulatorytcellsintype1autoimmunepancreatitis
AT fukuiyuri regulatorytcellsintype1autoimmunepancreatitis
AT sakaguchiyutaku regulatorytcellsintype1autoimmunepancreatitis
AT ikeuratsukasa regulatorytcellsintype1autoimmunepancreatitis
AT shimatanimasaaki regulatorytcellsintype1autoimmunepancreatitis
AT fukuitoshiro regulatorytcellsintype1autoimmunepancreatitis
AT matsushitamitsunobu regulatorytcellsintype1autoimmunepancreatitis
AT takaokamakoto regulatorytcellsintype1autoimmunepancreatitis
AT nishioakiyoshi regulatorytcellsintype1autoimmunepancreatitis
AT okazakikazuichi regulatorytcellsintype1autoimmunepancreatitis