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Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action

Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation...

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Autores principales: Nicastro, Humberto, da Luz, Claudia Ribeiro, Chaves, Daniela Fojo Seixas, Bechara, Luiz Roberto Grassmann, Voltarelli, Vanessa Azevedo, Rogero, Marcelo Macedo, Lancha, Antonio Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321450/
https://www.ncbi.nlm.nih.gov/pubmed/22536489
http://dx.doi.org/10.1155/2012/136937
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author Nicastro, Humberto
da Luz, Claudia Ribeiro
Chaves, Daniela Fojo Seixas
Bechara, Luiz Roberto Grassmann
Voltarelli, Vanessa Azevedo
Rogero, Marcelo Macedo
Lancha, Antonio Herbert
author_facet Nicastro, Humberto
da Luz, Claudia Ribeiro
Chaves, Daniela Fojo Seixas
Bechara, Luiz Roberto Grassmann
Voltarelli, Vanessa Azevedo
Rogero, Marcelo Macedo
Lancha, Antonio Herbert
author_sort Nicastro, Humberto
collection PubMed
description Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation.
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spelling pubmed-33214502012-04-25 Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action Nicastro, Humberto da Luz, Claudia Ribeiro Chaves, Daniela Fojo Seixas Bechara, Luiz Roberto Grassmann Voltarelli, Vanessa Azevedo Rogero, Marcelo Macedo Lancha, Antonio Herbert J Nutr Metab Review Article Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation. Hindawi Publishing Corporation 2012 2012-02-14 /pmc/articles/PMC3321450/ /pubmed/22536489 http://dx.doi.org/10.1155/2012/136937 Text en Copyright © 2012 Humberto Nicastro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nicastro, Humberto
da Luz, Claudia Ribeiro
Chaves, Daniela Fojo Seixas
Bechara, Luiz Roberto Grassmann
Voltarelli, Vanessa Azevedo
Rogero, Marcelo Macedo
Lancha, Antonio Herbert
Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
title Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
title_full Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
title_fullStr Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
title_full_unstemmed Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
title_short Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
title_sort does branched-chain amino acids supplementation modulate skeletal muscle remodeling through inflammation modulation? possible mechanisms of action
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321450/
https://www.ncbi.nlm.nih.gov/pubmed/22536489
http://dx.doi.org/10.1155/2012/136937
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