Overexpression of the Orotate Phosphoribosyl-Transferase Gene Enhances the Effect of 5-Fluorouracil in Head and Neck Squamous Cell Carcinoma In Vitro

5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). In the anabolic pathway of 5-FU, the first step in activation of the drug is phosphorylation of 5-FU by orotate phosphoribosyltransferase (OPRT), which directly metabolizes 5-FU to 5-fluorouridine monophosp...

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Detalles Bibliográficos
Autores principales: Yasumatsu, Ryuji, Nakashima, Torahiko, Komune, Shizuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321455/
https://www.ncbi.nlm.nih.gov/pubmed/22545049
http://dx.doi.org/10.1155/2012/649605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321455/
https://www.ncbi.nlm.nih.gov/pubmed/22545049
http://dx.doi.org/10.1155/2012/649605

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