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The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders

Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. The impetus for using various diets to treat – or at l...

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Autores principales: Stafstrom, Carl E., Rho, Jong M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321471/
https://www.ncbi.nlm.nih.gov/pubmed/22509165
http://dx.doi.org/10.3389/fphar.2012.00059
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author Stafstrom, Carl E.
Rho, Jong M.
author_facet Stafstrom, Carl E.
Rho, Jong M.
author_sort Stafstrom, Carl E.
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description Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. The impetus for using various diets to treat – or at least ameliorate symptoms of – these disorders stems from both a lack of effectiveness of pharmacological therapies, and also the intrinsic appeal of implementing a more “natural” treatment. The enormous spectrum of pathophysiological mechanisms underlying the aforementioned diseases would suggest a degree of complexity that cannot be impacted universally by any single dietary treatment. Yet, it is conceivable that alterations in certain dietary constituents could affect the course and impact the outcome of these brain disorders. Further, it is possible that a final common neurometabolic pathway might be influenced by a variety of dietary interventions. The most notable example of a dietary treatment with proven efficacy against a neurological condition is the high-fat, low-carbohydrate ketogenic diet (KD) used in patients with medically intractable epilepsy. While the mechanisms through which the KD works remain unclear, there is now compelling evidence that its efficacy is likely related to the normalization of aberrant energy metabolism. The concept that many neurological conditions are linked pathophysiologically to energy dysregulation could well provide a common research and experimental therapeutics platform, from which the course of several neurological diseases could be favorably influenced by dietary means. Here we provide an overview of studies using the KD in a wide panoply of neurologic disorders in which neuroprotection is an essential component.
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spelling pubmed-33214712012-04-16 The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders Stafstrom, Carl E. Rho, Jong M. Front Pharmacol Pharmacology Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. The impetus for using various diets to treat – or at least ameliorate symptoms of – these disorders stems from both a lack of effectiveness of pharmacological therapies, and also the intrinsic appeal of implementing a more “natural” treatment. The enormous spectrum of pathophysiological mechanisms underlying the aforementioned diseases would suggest a degree of complexity that cannot be impacted universally by any single dietary treatment. Yet, it is conceivable that alterations in certain dietary constituents could affect the course and impact the outcome of these brain disorders. Further, it is possible that a final common neurometabolic pathway might be influenced by a variety of dietary interventions. The most notable example of a dietary treatment with proven efficacy against a neurological condition is the high-fat, low-carbohydrate ketogenic diet (KD) used in patients with medically intractable epilepsy. While the mechanisms through which the KD works remain unclear, there is now compelling evidence that its efficacy is likely related to the normalization of aberrant energy metabolism. The concept that many neurological conditions are linked pathophysiologically to energy dysregulation could well provide a common research and experimental therapeutics platform, from which the course of several neurological diseases could be favorably influenced by dietary means. Here we provide an overview of studies using the KD in a wide panoply of neurologic disorders in which neuroprotection is an essential component. Frontiers Research Foundation 2012-04-09 /pmc/articles/PMC3321471/ /pubmed/22509165 http://dx.doi.org/10.3389/fphar.2012.00059 Text en Copyright © 2012 Stafstrom and Rho. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Pharmacology
Stafstrom, Carl E.
Rho, Jong M.
The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
title The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
title_full The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
title_fullStr The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
title_full_unstemmed The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
title_short The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
title_sort ketogenic diet as a treatment paradigm for diverse neurological disorders
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321471/
https://www.ncbi.nlm.nih.gov/pubmed/22509165
http://dx.doi.org/10.3389/fphar.2012.00059
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