Cargando…

Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes

Liver transplantation has been a successful therapy for liver failure. However, a significant number of recipients suffer from graft dysfunction. Considerably, ischemia and reperfusion (I/R) injury is the most important factor leading to organ dysfunction, although the pathogenesis has not been full...

Descripción completa

Detalles Bibliográficos
Autores principales: Sergi, Consolato, Abdualmjid, Reem, Abuetabh, Yasser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321507/
https://www.ncbi.nlm.nih.gov/pubmed/22536013
http://dx.doi.org/10.1155/2012/131324
_version_ 1782228953765773312
author Sergi, Consolato
Abdualmjid, Reem
Abuetabh, Yasser
author_facet Sergi, Consolato
Abdualmjid, Reem
Abuetabh, Yasser
author_sort Sergi, Consolato
collection PubMed
description Liver transplantation has been a successful therapy for liver failure. However, a significant number of recipients suffer from graft dysfunction. Considerably, ischemia and reperfusion (I/R) injury is the most important factor leading to organ dysfunction, although the pathogenesis has not been fully described. I/R injury have several established features that are accompanied by and/or linked to bile duct loss or ductopenia, cholestasis, and biliary ductular proliferations in the posttransplant liver biopsy. However, biliary marker levels increase usually only 5–7 days after transplantation. Intermediate filaments are one of the three cytoskeletal proteins that have a major role in liver protection and maintaining both cellular structure and integrity of eukaryotic cells. We reviewed the canine liver transplantation model as I/R injury model to delineate the intermediate filaments of the cytoskeleton that are probably the determinants in changing the phenotype of hepatocytes to cholangiocytes. Remarkably, this interesting feature seems to occur earlier than frank cholestasis. We speculate that I/R liver injury through a phenotypical switch of the hepatocytes may contribute to the poor outcome of the liver graft.
format Online
Article
Text
id pubmed-3321507
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33215072012-04-25 Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes Sergi, Consolato Abdualmjid, Reem Abuetabh, Yasser J Biomed Biotechnol Review Article Liver transplantation has been a successful therapy for liver failure. However, a significant number of recipients suffer from graft dysfunction. Considerably, ischemia and reperfusion (I/R) injury is the most important factor leading to organ dysfunction, although the pathogenesis has not been fully described. I/R injury have several established features that are accompanied by and/or linked to bile duct loss or ductopenia, cholestasis, and biliary ductular proliferations in the posttransplant liver biopsy. However, biliary marker levels increase usually only 5–7 days after transplantation. Intermediate filaments are one of the three cytoskeletal proteins that have a major role in liver protection and maintaining both cellular structure and integrity of eukaryotic cells. We reviewed the canine liver transplantation model as I/R injury model to delineate the intermediate filaments of the cytoskeleton that are probably the determinants in changing the phenotype of hepatocytes to cholangiocytes. Remarkably, this interesting feature seems to occur earlier than frank cholestasis. We speculate that I/R liver injury through a phenotypical switch of the hepatocytes may contribute to the poor outcome of the liver graft. Hindawi Publishing Corporation 2012 2012-03-28 /pmc/articles/PMC3321507/ /pubmed/22536013 http://dx.doi.org/10.1155/2012/131324 Text en Copyright © 2012 Consolato Sergi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sergi, Consolato
Abdualmjid, Reem
Abuetabh, Yasser
Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
title Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
title_full Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
title_fullStr Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
title_full_unstemmed Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
title_short Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
title_sort canine liver transplantation model and the intermediate filaments of the cytoskeleton of the hepatocytes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321507/
https://www.ncbi.nlm.nih.gov/pubmed/22536013
http://dx.doi.org/10.1155/2012/131324
work_keys_str_mv AT sergiconsolato caninelivertransplantationmodelandtheintermediatefilamentsofthecytoskeletonofthehepatocytes
AT abdualmjidreem caninelivertransplantationmodelandtheintermediatefilamentsofthecytoskeletonofthehepatocytes
AT abuetabhyasser caninelivertransplantationmodelandtheintermediatefilamentsofthecytoskeletonofthehepatocytes