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Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms
The glial environment is an important determinant of neuronal health in experimental models of neurodegeneration. Specifically, astrocytes have been shown, dependent on context, to be both injurious and protective. Human pluripotent stem cells offer a powerful new system to improve our understanding...
Autores principales: | Gupta, K, Patani, R, Baxter, P, Serio, A, Story, D, Tsujita, T, Hayes, J D, Pedersen, R A, Hardingham, G E, Chandran, S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321621/ https://www.ncbi.nlm.nih.gov/pubmed/22095276 http://dx.doi.org/10.1038/cdd.2011.154 |
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