Evolution of New Genotype of West Nile Virus in North America

Previous studies of North American isolates of West Nile virus (WNV) during 1999–2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002–2009 suggests that this is not the case. Three new genet...

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Autores principales: McMullen, Allison R., May, Fiona J., Li, Li, Guzman, Hilda, Bueno, Rudy, Dennett, James A., Tesh, Robert B., Barrett, Alan D.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321787/
https://www.ncbi.nlm.nih.gov/pubmed/21529385
http://dx.doi.org/10.3201/eid1705.101707
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author McMullen, Allison R.
May, Fiona J.
Li, Li
Guzman, Hilda
Bueno, Rudy
Dennett, James A.
Tesh, Robert B.
Barrett, Alan D.T.
author_facet McMullen, Allison R.
May, Fiona J.
Li, Li
Guzman, Hilda
Bueno, Rudy
Dennett, James A.
Tesh, Robert B.
Barrett, Alan D.T.
author_sort McMullen, Allison R.
collection PubMed
description Previous studies of North American isolates of West Nile virus (WNV) during 1999–2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002–2009 suggests that this is not the case. Three new genetic groups have been identified in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World.
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spelling pubmed-33217872012-04-27 Evolution of New Genotype of West Nile Virus in North America McMullen, Allison R. May, Fiona J. Li, Li Guzman, Hilda Bueno, Rudy Dennett, James A. Tesh, Robert B. Barrett, Alan D.T. Emerg Infect Dis Research Previous studies of North American isolates of West Nile virus (WNV) during 1999–2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002–2009 suggests that this is not the case. Three new genetic groups have been identified in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World. Centers for Disease Control and Prevention 2011-05 /pmc/articles/PMC3321787/ /pubmed/21529385 http://dx.doi.org/10.3201/eid1705.101707 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
McMullen, Allison R.
May, Fiona J.
Li, Li
Guzman, Hilda
Bueno, Rudy
Dennett, James A.
Tesh, Robert B.
Barrett, Alan D.T.
Evolution of New Genotype of West Nile Virus in North America
title Evolution of New Genotype of West Nile Virus in North America
title_full Evolution of New Genotype of West Nile Virus in North America
title_fullStr Evolution of New Genotype of West Nile Virus in North America
title_full_unstemmed Evolution of New Genotype of West Nile Virus in North America
title_short Evolution of New Genotype of West Nile Virus in North America
title_sort evolution of new genotype of west nile virus in north america
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321787/
https://www.ncbi.nlm.nih.gov/pubmed/21529385
http://dx.doi.org/10.3201/eid1705.101707
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