Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients

Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a diss...

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Autores principales: Al Akhrass, Fadi, Hachem, Ray, Mohamed, Jamal A., Tarrand, Jeffrey, Kontoyiannis, Dimitrios P., Chandra, Jyotsna, Ghannoum, Mahmoud, Haydoura, Souha, Chaftari, Ann Marie, Raad, Issam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322064/
https://www.ncbi.nlm.nih.gov/pubmed/21888790
http://dx.doi.org/10.3201/eid1709.101810
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author Al Akhrass, Fadi
Hachem, Ray
Mohamed, Jamal A.
Tarrand, Jeffrey
Kontoyiannis, Dimitrios P.
Chandra, Jyotsna
Ghannoum, Mahmoud
Haydoura, Souha
Chaftari, Ann Marie
Raad, Issam
author_facet Al Akhrass, Fadi
Hachem, Ray
Mohamed, Jamal A.
Tarrand, Jeffrey
Kontoyiannis, Dimitrios P.
Chandra, Jyotsna
Ghannoum, Mahmoud
Haydoura, Souha
Chaftari, Ann Marie
Raad, Issam
author_sort Al Akhrass, Fadi
collection PubMed
description Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a disseminated infection. N. nova complex was the leading cause of bacteremia. Nocardia promoted heavy biofilm formation on the surface of central venous catheter segments tested in an in vitro biofilm model. Trimethoprim- and minocycline-based lock solutions had potent in vitro activity against biofilm growth. Patients with Nocardia central venous catheter–associated bloodstream infections responded well to catheter removal and antimicrobial drug therapy, whereas those with disseminated bacteremia had poor prognoses.
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spelling pubmed-33220642012-04-30 Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients Al Akhrass, Fadi Hachem, Ray Mohamed, Jamal A. Tarrand, Jeffrey Kontoyiannis, Dimitrios P. Chandra, Jyotsna Ghannoum, Mahmoud Haydoura, Souha Chaftari, Ann Marie Raad, Issam Emerg Infect Dis Research Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a disseminated infection. N. nova complex was the leading cause of bacteremia. Nocardia promoted heavy biofilm formation on the surface of central venous catheter segments tested in an in vitro biofilm model. Trimethoprim- and minocycline-based lock solutions had potent in vitro activity against biofilm growth. Patients with Nocardia central venous catheter–associated bloodstream infections responded well to catheter removal and antimicrobial drug therapy, whereas those with disseminated bacteremia had poor prognoses. Centers for Disease Control and Prevention 2011-09 /pmc/articles/PMC3322064/ /pubmed/21888790 http://dx.doi.org/10.3201/eid1709.101810 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Al Akhrass, Fadi
Hachem, Ray
Mohamed, Jamal A.
Tarrand, Jeffrey
Kontoyiannis, Dimitrios P.
Chandra, Jyotsna
Ghannoum, Mahmoud
Haydoura, Souha
Chaftari, Ann Marie
Raad, Issam
Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
title Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
title_full Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
title_fullStr Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
title_full_unstemmed Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
title_short Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients
title_sort central venous catheter–associated nocardia bacteremia in cancer patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322064/
https://www.ncbi.nlm.nih.gov/pubmed/21888790
http://dx.doi.org/10.3201/eid1709.101810
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