Sialyl Residues Modulate LPS-Mediated Signaling through the Toll-Like Receptor 4 Complex

We previously reported that neuraminidase (NA) pretreatment of human PBMCs markedly increased their cytokine response to lipopolysaccharide (LPS). To study the mechanisms by which this occurs, we transfected HEK293T cells with plasmids encoding TLR4, CD14, and MD2 (three components of the LPS recept...

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Detalles Bibliográficos
Autores principales: Feng, Chiguang, Stamatos, Nicholas M., Dragan, Anatoliy I., Medvedev, Andrei, Whitford, Melissa, Zhang, Lei, Song, Chang, Rallabhandi, Prasad, Cole, Leah, Nhu, Quan M., Vogel, Stefanie N., Geddes, Chris D., Cross, Alan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322133/
https://www.ncbi.nlm.nih.gov/pubmed/22496731
http://dx.doi.org/10.1371/journal.pone.0032359

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