Cargando…

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

LRRK2, a Parkinson's disease associated gene, is highly expressed in microglia in addition to neurons; however, its function in microglia has not been evaluated. Using Lrrk2 knockdown (Lrrk2-KD) murine microglia prepared by lentiviral-mediated transfer of Lrrk2-specific small inhibitory hairpin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Beomsue, Yang, Myung-Soon, Choi, Dongjoo, Kim, Jong-Hyeon, Kim, Hye-Sun, Seol, Wongi, Choi, Sangdun, Jou, Ilo, Kim, Eun-Young, Joe, Eun-hye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322140/ https://www.ncbi.nlm.nih.gov/pubmed/22496842 http://dx.doi.org/10.1371/journal.pone.0034693

Ejemplares similares

Suppression of miR-155 Expression in IFN-γ-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression
por: Kim, Jong-hyeon, et al.
Publicado: (2014)

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
por: Choi, Insup, et al.
Publicado: (2015)

Astrocytes, Microglia, and Parkinson's Disease
por: Joe, Eun-Hye, et al.
Publicado: (2018)

Inflammatory Responses Are Not Sufficient to Cause Delayed Neuronal Death in ATP-Induced Acute Brain Injury
por: Jeong, Hey-Kyeong, et al.
Publicado: (2010)

LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
por: Choi, Insup, et al.
Publicado: (2016)

Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes
por: Lee, Jee Hoon, et al.
Publicado: (2019)

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy
por: Park, Sangwook, et al.
Publicado: (2016)

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5
por: Heo, Hye Young, et al.
Publicado: (2010)

Small heterodimer partner (SHP) aggravates ER stress in Parkinson’s disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation
por: Lee, Jee Hoon, et al.
Publicado: (2021)

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
por: Ho, Dong Hwan, et al.
Publicado: (2016)

PINK1 Deficiency Attenuates Astrocyte Proliferation Through Mitochondrial Dysfunction, Reduced AKT and Increased p38 MAPK Activation, and Downregulation of EGFR
por: Choi, Insup, et al.
Publicado: (2013)

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
por: Ho, Dong Hwan, et al.
Publicado: (2018)

Spatial and temporal correlation in progressive degeneration of neurons and astrocytes in contusion-induced spinal cord injury
por: Min, Kyoung-Jin, et al.
Publicado: (2012)

PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices
por: Kim, Jun, et al.
Publicado: (2013)

LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition
por: Kim, Beomsue, et al.
Publicado: (2022)

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression
por: Kim, Jin-Mo, et al.
Publicado: (2016)

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
por: Yun, Hye Jin, et al.
Publicado: (2013)

PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation
por: Choi, Insup, et al.
Publicado: (2016)

Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons
por: Kim, Hyejung, et al.
Publicado: (2021)

Rab GTPases as Physiological Substrates of LRRK2 Kinase
por: Seol, Wongi, et al.
Publicado: (2019)

Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells
por: Park, Soo Jung, et al.
Publicado: (2019)

Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner
por: Park, Ji-Min, et al.
Publicado: (2013)

5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability
por: Lee, Jee Hoon, et al.
Publicado: (2012)

Repair of astrocytes, blood vessels, and myelin in the injured brain: possible roles of blood monocytes
por: Jeong, Hey-Kyeong, et al.
Publicado: (2013)

Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson’s disease
por: Nam, Daleum, et al.
Publicado: (2021)

Absence of Delayed Neuronal Death in ATP-Injected Brain: Possible Roles of Astrogliosis
por: Jeong, Hey-Kyeong, et al.
Publicado: (2013)

Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease
por: Cha, Seon-Heui, et al.
Publicado: (2015)

Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum
por: Yang, Haijie, et al.
Publicado: (2020)

Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases
por: Woo, Joo Hong, et al.
Publicado: (2015)

G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses
por: Ho, Dong Hwan, et al.
Publicado: (2019)

Astrogliosis Is a Possible Player in Preventing Delayed Neuronal Death
por: Jeong, Hey-Kyeong, et al.
Publicado: (2014)

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2015)

Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl(2) negatively regulates neurosphere formation in culture
por: Kwon, Jae-Kyung, et al.
Publicado: (2021)

Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2017)

STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
por: Kim, Hyunmi, et al.
Publicado: (2022)

LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells
por: Ho, Dong Hwan, et al.
Publicado: (2021)

Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity
por: Jang, Jihoon, et al.
Publicado: (2018)

Erratum to: PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAPpositive astrocytes
por: Choi, Insup, et al.
Publicado: (2016)

PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes
por: Choi, Insup, et al.
Publicado: (2016)

Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1
por: Han, Kyung A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h0u75svnpv024tf47i67aef57o