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Direct Observation of Strand Passage by DNA-Topoisomerase and Its Limited Processivity
Type-II DNA topoisomerases resolve DNA entanglements such as supercoils, knots and catenanes by passing one segment of DNA duplex through a transient enzyme-bridged double-stranded break in another segment. The ATP-dependent passage reaction has previously been demonstrated at the single-molecule le...
Autores principales: | Yogo, Katsunori, Ogawa, Taisaku, Hayashi, Masahito, Harada, Yoshie, Nishizaka, Takayuki, Kinosita, Kazuhiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322154/ https://www.ncbi.nlm.nih.gov/pubmed/22496876 http://dx.doi.org/10.1371/journal.pone.0034920 |
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