Cargando…

Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence

It is rare for low-grade gliomas to disseminate to the leptomeninges. However, low-grade gliomas with dissemination to the leptomeninges have been occasionally reported in children, and have generally been associated with local recurrence. A 16-year-old boy sought evaluation for diplopia and gait di...

Descripción completa

Detalles Bibliográficos
Autores principales: Moon, Jung-Ho, Jung, Tae-Young, Jung, Shin, Jang, Woo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Neurosurgical Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322207/
https://www.ncbi.nlm.nih.gov/pubmed/22500205
http://dx.doi.org/10.3340/jkns.2012.51.2.109
_version_ 1782229049975767040
author Moon, Jung-Ho
Jung, Tae-Young
Jung, Shin
Jang, Woo-Youl
author_facet Moon, Jung-Ho
Jung, Tae-Young
Jung, Shin
Jang, Woo-Youl
author_sort Moon, Jung-Ho
collection PubMed
description It is rare for low-grade gliomas to disseminate to the leptomeninges. However, low-grade gliomas with dissemination to the leptomeninges have been occasionally reported in children, and have generally been associated with local recurrence. A 16-year-old boy sought evaluation for diplopia and gait disturbance. A brain magnetic resonance imaging (MRI) revealed pontine mass, which was proved to be fibrillary astrocytoma on biopsy, later. Radiation therapy (5400 cGy) was given and the patient's symptoms were improved. He was followed-up radiologically for brain lesion. Seven months after diagnosis he complained of back pain and gait disturbance. A brain MRI showed a newly-developed lesion at the left cerebellopontine angle without an interval change in the primary lesion. A spinal MRI demonstrated leptomeningeal dissemination of the entire spine. Radiation therapy (3750 cGy) to the spine, and adjuvant chemotherapy with a carboplatin plus vincristine regimen were administered. However, he had a progressive course with tumoral hemorrhage and expired 13 months after diagnosis. We report an unusual case of a low-grade brainstem glioma with spinal dissemination, but without local recurrence, and a progressive course associated with hemorrhage.
format Online
Article
Text
id pubmed-3322207
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Korean Neurosurgical Society
record_format MEDLINE/PubMed
spelling pubmed-33222072012-04-12 Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence Moon, Jung-Ho Jung, Tae-Young Jung, Shin Jang, Woo-Youl J Korean Neurosurg Soc Case Report It is rare for low-grade gliomas to disseminate to the leptomeninges. However, low-grade gliomas with dissemination to the leptomeninges have been occasionally reported in children, and have generally been associated with local recurrence. A 16-year-old boy sought evaluation for diplopia and gait disturbance. A brain magnetic resonance imaging (MRI) revealed pontine mass, which was proved to be fibrillary astrocytoma on biopsy, later. Radiation therapy (5400 cGy) was given and the patient's symptoms were improved. He was followed-up radiologically for brain lesion. Seven months after diagnosis he complained of back pain and gait disturbance. A brain MRI showed a newly-developed lesion at the left cerebellopontine angle without an interval change in the primary lesion. A spinal MRI demonstrated leptomeningeal dissemination of the entire spine. Radiation therapy (3750 cGy) to the spine, and adjuvant chemotherapy with a carboplatin plus vincristine regimen were administered. However, he had a progressive course with tumoral hemorrhage and expired 13 months after diagnosis. We report an unusual case of a low-grade brainstem glioma with spinal dissemination, but without local recurrence, and a progressive course associated with hemorrhage. The Korean Neurosurgical Society 2012-02 2012-02-29 /pmc/articles/PMC3322207/ /pubmed/22500205 http://dx.doi.org/10.3340/jkns.2012.51.2.109 Text en Copyright © 2012 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Moon, Jung-Ho
Jung, Tae-Young
Jung, Shin
Jang, Woo-Youl
Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
title Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
title_full Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
title_fullStr Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
title_full_unstemmed Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
title_short Leptomeningeal Dissemination of a Low-Grade Brainstem Glioma without Local Recurrence
title_sort leptomeningeal dissemination of a low-grade brainstem glioma without local recurrence
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322207/
https://www.ncbi.nlm.nih.gov/pubmed/22500205
http://dx.doi.org/10.3340/jkns.2012.51.2.109
work_keys_str_mv AT moonjungho leptomeningealdisseminationofalowgradebrainstemgliomawithoutlocalrecurrence
AT jungtaeyoung leptomeningealdisseminationofalowgradebrainstemgliomawithoutlocalrecurrence
AT jungshin leptomeningealdisseminationofalowgradebrainstemgliomawithoutlocalrecurrence
AT jangwooyoul leptomeningealdisseminationofalowgradebrainstemgliomawithoutlocalrecurrence