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Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?

Rheumatoid arthritis (RA) is a long-term disease that leads to inflammation of the joints and surrounding tissues. Natural killer (NK) cells are an important part of the innate immune system and are responsible for the first line of defense against pathogens during the initial immune challenge befor...

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Detalles Bibliográficos
Autores principales: Shegarfi, Hamid, Naddafi, Fatemeh, Mirshafiey, Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322405/
https://www.ncbi.nlm.nih.gov/pubmed/22547986
http://dx.doi.org/10.1100/2012/491974
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author Shegarfi, Hamid
Naddafi, Fatemeh
Mirshafiey, Abbas
author_facet Shegarfi, Hamid
Naddafi, Fatemeh
Mirshafiey, Abbas
author_sort Shegarfi, Hamid
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description Rheumatoid arthritis (RA) is a long-term disease that leads to inflammation of the joints and surrounding tissues. Natural killer (NK) cells are an important part of the innate immune system and are responsible for the first line of defense against pathogens during the initial immune challenge before the adaptive immune system eventually eliminates the infectious burden. NK cells have the capacity to damage normal cells or through interaction with other cells such as dendritic cells, macrophages, and T cells cause autoimmune diseases, such as RA. NK cells isolated from the joints of patients with RA suggest that they may play a role in this disease. However, the involvement of NK cells in RA pathology is not fully elucidated. Both protective and detrimental roles of NK cells in RA have recently been reported. A better understanding of NK cells' role in RA might help to develop new therapeutic strategies for treatment of the RA or other autoimmune diseases. We have decided in this paper to focus on the NK cell biology, and attempt to bring the interested readership of this Journal up to date on the NK cell, specifically its possible relation to RA.
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spelling pubmed-33224052012-04-30 Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe? Shegarfi, Hamid Naddafi, Fatemeh Mirshafiey, Abbas ScientificWorldJournal Review Article Rheumatoid arthritis (RA) is a long-term disease that leads to inflammation of the joints and surrounding tissues. Natural killer (NK) cells are an important part of the innate immune system and are responsible for the first line of defense against pathogens during the initial immune challenge before the adaptive immune system eventually eliminates the infectious burden. NK cells have the capacity to damage normal cells or through interaction with other cells such as dendritic cells, macrophages, and T cells cause autoimmune diseases, such as RA. NK cells isolated from the joints of patients with RA suggest that they may play a role in this disease. However, the involvement of NK cells in RA pathology is not fully elucidated. Both protective and detrimental roles of NK cells in RA have recently been reported. A better understanding of NK cells' role in RA might help to develop new therapeutic strategies for treatment of the RA or other autoimmune diseases. We have decided in this paper to focus on the NK cell biology, and attempt to bring the interested readership of this Journal up to date on the NK cell, specifically its possible relation to RA. The Scientific World Journal 2012-04-01 /pmc/articles/PMC3322405/ /pubmed/22547986 http://dx.doi.org/10.1100/2012/491974 Text en Copyright © 2012 Hamid Shegarfi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shegarfi, Hamid
Naddafi, Fatemeh
Mirshafiey, Abbas
Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?
title Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?
title_full Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?
title_fullStr Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?
title_full_unstemmed Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?
title_short Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?
title_sort natural killer cells and their role in rheumatoid arthritis: friend or foe?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322405/
https://www.ncbi.nlm.nih.gov/pubmed/22547986
http://dx.doi.org/10.1100/2012/491974
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