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Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex
A debated question in the literature is the degree of anatomical and functional lateralization of the executive control processes sub-served by the dorsolateral prefrontal cortex (DLPFC) during recognition memory retrieval. We investigated if transient inhibition and excitation of the left and right...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322484/ https://www.ncbi.nlm.nih.gov/pubmed/22514525 http://dx.doi.org/10.3389/fnhum.2012.00062 |
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author | Turriziani, Patrizia Smirni, Daniela Zappalà, Giuseppe Mangano, Giuseppa R. Oliveri, Massimiliano Cipolotti, Lisa |
author_facet | Turriziani, Patrizia Smirni, Daniela Zappalà, Giuseppe Mangano, Giuseppa R. Oliveri, Massimiliano Cipolotti, Lisa |
author_sort | Turriziani, Patrizia |
collection | PubMed |
description | A debated question in the literature is the degree of anatomical and functional lateralization of the executive control processes sub-served by the dorsolateral prefrontal cortex (DLPFC) during recognition memory retrieval. We investigated if transient inhibition and excitation of the left and right DLPFC at retrieval by means of repetitive transcranial magnetic stimulation (rTMS) modulate recognition memory performance in 100 healthy controls (HCs) and in eight patients with Mild Cognitive Impairment (MCI). Recognition memory tasks of faces, buildings, and words were used in different experiments. rTMS-inhibition of the right DLPFC enhanced recognition memory in both HCs and MCIs. rTMS-excitation of the same region in HCs deteriorated memory performance. Inhibition of the right DLPFC could modulate the excitability of a network of brain regions, in the ipsilateral as well as in the contralateral hemisphere, enhancing function in HCs or restoring an adaptive equilibrium in MCI. |
format | Online Article Text |
id | pubmed-3322484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-33224842012-04-18 Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex Turriziani, Patrizia Smirni, Daniela Zappalà, Giuseppe Mangano, Giuseppa R. Oliveri, Massimiliano Cipolotti, Lisa Front Hum Neurosci Neuroscience A debated question in the literature is the degree of anatomical and functional lateralization of the executive control processes sub-served by the dorsolateral prefrontal cortex (DLPFC) during recognition memory retrieval. We investigated if transient inhibition and excitation of the left and right DLPFC at retrieval by means of repetitive transcranial magnetic stimulation (rTMS) modulate recognition memory performance in 100 healthy controls (HCs) and in eight patients with Mild Cognitive Impairment (MCI). Recognition memory tasks of faces, buildings, and words were used in different experiments. rTMS-inhibition of the right DLPFC enhanced recognition memory in both HCs and MCIs. rTMS-excitation of the same region in HCs deteriorated memory performance. Inhibition of the right DLPFC could modulate the excitability of a network of brain regions, in the ipsilateral as well as in the contralateral hemisphere, enhancing function in HCs or restoring an adaptive equilibrium in MCI. Frontiers Media S.A. 2012-04-10 /pmc/articles/PMC3322484/ /pubmed/22514525 http://dx.doi.org/10.3389/fnhum.2012.00062 Text en Copyright © 2012 Turriziani, Smirni, Zappalà, Mangano, Oliveri and Cipolotti. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Neuroscience Turriziani, Patrizia Smirni, Daniela Zappalà, Giuseppe Mangano, Giuseppa R. Oliveri, Massimiliano Cipolotti, Lisa Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex |
title | Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex |
title_full | Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex |
title_fullStr | Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex |
title_full_unstemmed | Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex |
title_short | Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex |
title_sort | enhancing memory performance with rtms in healthy subjects and individuals with mild cognitive impairment: the role of the right dorsolateral prefrontal cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322484/ https://www.ncbi.nlm.nih.gov/pubmed/22514525 http://dx.doi.org/10.3389/fnhum.2012.00062 |
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