Immunofluorescence Assay for Serologic Diagnosis of SARS

We evaluated a virus-infected cell-based indirect immunofluorescence assay for detecting anti–severe acute respiratory syndrome-associated coronavirus (SARS-CoV) immunoglobulin (Ig) G antibody. All confirmed SARS cases demonstrated seroconversion or fourfold rise in IgG antibody titer; no control wa...

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Detalles Bibliográficos
Autores principales: Chan, Paul K. S., Ng, King-Cheung, Chan, Rickjason C. W., Lam, Rebecca K. Y., Chow, Viola C. Y., Hui, Mamie, Wu, Alan, Lee, Nelson, Yap, Florence H.Y., Cheng, Frankie W. T., Sung, Joseph J. Y., Tam, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2004
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322771/
https://www.ncbi.nlm.nih.gov/pubmed/15109430
http://dx.doi.org/10.3201/eid1003.030493
Descripción
Sumario:We evaluated a virus-infected cell-based indirect immunofluorescence assay for detecting anti–severe acute respiratory syndrome-associated coronavirus (SARS-CoV) immunoglobulin (Ig) G antibody. All confirmed SARS cases demonstrated seroconversion or fourfold rise in IgG antibody titer; no control was positive. Sensitivity and specificity of this assay were both 100%. Immunofluorescence assay can ascertain the status of SARS-CoV infection.

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