Cargando…

Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome

Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have r...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Chunyan, Prescott, Joseph, Nofchissey, Robert, Goade, Diane, Hjelle, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322788/
https://www.ncbi.nlm.nih.gov/pubmed/15109416
http://dx.doi.org/10.3201/eid1003.020821
_version_ 1782229106602016768
author Ye, Chunyan
Prescott, Joseph
Nofchissey, Robert
Goade, Diane
Hjelle, Brian
author_facet Ye, Chunyan
Prescott, Joseph
Nofchissey, Robert
Goade, Diane
Hjelle, Brian
author_sort Ye, Chunyan
collection PubMed
description Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection.
format Online
Article
Text
id pubmed-3322788
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-33227882012-04-16 Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome Ye, Chunyan Prescott, Joseph Nofchissey, Robert Goade, Diane Hjelle, Brian Emerg Infect Dis Research Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection. Centers for Disease Control and Prevention 2004-03 /pmc/articles/PMC3322788/ /pubmed/15109416 http://dx.doi.org/10.3201/eid1003.020821 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Ye, Chunyan
Prescott, Joseph
Nofchissey, Robert
Goade, Diane
Hjelle, Brian
Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
title Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
title_full Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
title_fullStr Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
title_full_unstemmed Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
title_short Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
title_sort neutralizing antibodies and sin nombre virus rna after recovery from hantavirus cardiopulmonary syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322788/
https://www.ncbi.nlm.nih.gov/pubmed/15109416
http://dx.doi.org/10.3201/eid1003.020821
work_keys_str_mv AT yechunyan neutralizingantibodiesandsinnombrevirusrnaafterrecoveryfromhantaviruscardiopulmonarysyndrome
AT prescottjoseph neutralizingantibodiesandsinnombrevirusrnaafterrecoveryfromhantaviruscardiopulmonarysyndrome
AT nofchisseyrobert neutralizingantibodiesandsinnombrevirusrnaafterrecoveryfromhantaviruscardiopulmonarysyndrome
AT goadediane neutralizingantibodiesandsinnombrevirusrnaafterrecoveryfromhantaviruscardiopulmonarysyndrome
AT hjellebrian neutralizingantibodiesandsinnombrevirusrnaafterrecoveryfromhantaviruscardiopulmonarysyndrome