Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer

BACKGROUND: Increased Aurora kinase A gene copy number (AURKA-CN) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to clinical outcome. We correlated increased AURKA-CN in mCRC tumours with KRAS mutation status, overall and progression-free survival (OS, PFS). METH...

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Detalles Bibliográficos
Autores principales: Dotan, E, Meropol, N J, Zhu, F, Zambito, F, Bove, B, Cai, K Q, Godwin, A K, Golemis, E A, Astsaturov, I, Cohen, S J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322945/
https://www.ncbi.nlm.nih.gov/pubmed/22240781
http://dx.doi.org/10.1038/bjc.2011.587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322945/
https://www.ncbi.nlm.nih.gov/pubmed/22240781
http://dx.doi.org/10.1038/bjc.2011.587

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