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Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer
BACKGROUND: Increased Aurora kinase A gene copy number (AURKA-CN) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to clinical outcome. We correlated increased AURKA-CN in mCRC tumours with KRAS mutation status, overall and progression-free survival (OS, PFS). METH...
Autores principales: | Dotan, E, Meropol, N J, Zhu, F, Zambito, F, Bove, B, Cai, K Q, Godwin, A K, Golemis, E A, Astsaturov, I, Cohen, S J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322945/ https://www.ncbi.nlm.nih.gov/pubmed/22240781 http://dx.doi.org/10.1038/bjc.2011.587 |
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