The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells

BACKGROUND: Resistance to chemotherapeutic agents has been associated with a failure of cancer cells to induce apoptosis. Strategies to restore apoptosis have led to the development of BH3 mimetics, which inhibit anti-apoptotic Bcl-2 family members. We examined the sensitivity of three oesophageal c...

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Detalles Bibliográficos
Autores principales: Nyhan, M J, O'Donovan, T R, Elzinga, B, Crowley, L C, O'Sullivan, G C, McKenna, S L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322956/
https://www.ncbi.nlm.nih.gov/pubmed/22240779
http://dx.doi.org/10.1038/bjc.2011.604

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