Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding

M-channels are voltage-gated potassium channels that regulate cell excitability. They are heterotetrameric assemblies of Kv7.2 and Kv7.3 subunits. Their opening requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). However, the specificity of PI(4,5)...

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Detalles Bibliográficos
Autores principales: Telezhkin, Vsevolod, Reilly, Joanne M., Thomas, Alison M., Tinker, Andrew, Brown, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322975/
https://www.ncbi.nlm.nih.gov/pubmed/22303005
http://dx.doi.org/10.1074/jbc.M111.322552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322975/
https://www.ncbi.nlm.nih.gov/pubmed/22303005
http://dx.doi.org/10.1074/jbc.M111.322552

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