Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression

Atovaquone is an anti-malarial drug used in combination with proguanil (e.g. Malarone(TM)) for the curative and prophylactic treatment of malaria. Atovaquone, a 2-hydroxynaphthoquinone, is a competitive inhibitor of the quinol oxidation (Q(o)) site of the mitochondrial cytochrome bc(1) complex. Inhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley J., Johnson, David J., Lawrenson, Alexandre S., Ranson, Hilary, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322985/
https://www.ncbi.nlm.nih.gov/pubmed/22282497
http://dx.doi.org/10.1074/jbc.M111.324319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322985/
https://www.ncbi.nlm.nih.gov/pubmed/22282497
http://dx.doi.org/10.1074/jbc.M111.324319

Ejemplares similares