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Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression

Atovaquone is an anti-malarial drug used in combination with proguanil (e.g. Malarone(TM)) for the curative and prophylactic treatment of malaria. Atovaquone, a 2-hydroxynaphthoquinone, is a competitive inhibitor of the quinol oxidation (Q(o)) site of the mitochondrial cytochrome bc(1) complex. Inhi...

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Detalles Bibliográficos
Autores principales:	Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley J., Johnson, David J., Lawrenson, Alexandre S., Ranson, Hilary, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322985/ https://www.ncbi.nlm.nih.gov/pubmed/22282497 http://dx.doi.org/10.1074/jbc.M111.324319

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