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Babesia divergens–like Infection, Washington State

Most reported U.S. zoonotic cases of babesiosis have occurred in the Northeast and been caused by Babesia microti. In Washington State, three cases of babesiosis have been reported previously, which were caused by WA1 (for “Washington 1”)-type parasites. We investigated a case of babesiosis in Washi...

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Autores principales: Herwaldt, Barbara L., de Bruyn, Guy, Pieniazek, Norman J., Homer, Mary, Lofy, Kathryn H., Slemenda, Susan B., Fritsche, Thomas R., Persing, David H., Limaye, Ajit P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323086/
https://www.ncbi.nlm.nih.gov/pubmed/15200851
http://dx.doi.org/10.3201/eid1004.030377
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author Herwaldt, Barbara L.
de Bruyn, Guy
Pieniazek, Norman J.
Homer, Mary
Lofy, Kathryn H.
Slemenda, Susan B.
Fritsche, Thomas R.
Persing, David H.
Limaye, Ajit P.
author_facet Herwaldt, Barbara L.
de Bruyn, Guy
Pieniazek, Norman J.
Homer, Mary
Lofy, Kathryn H.
Slemenda, Susan B.
Fritsche, Thomas R.
Persing, David H.
Limaye, Ajit P.
author_sort Herwaldt, Barbara L.
collection PubMed
description Most reported U.S. zoonotic cases of babesiosis have occurred in the Northeast and been caused by Babesia microti. In Washington State, three cases of babesiosis have been reported previously, which were caused by WA1 (for “Washington 1”)-type parasites. We investigated a case of babesiosis in Washington in an 82–year-old man whose spleen had been removed and whose parasitemia level was 41.4%. The complete 18S ribosomal RNA gene of the parasite was amplified from specimens of his whole blood by polymerase chain reaction. Phylogenetic analysis showed the parasite is most closely related, but not identical, to B. divergens (similarity score, 99.5%), a bovine parasite in Europe. By indirect fluorescent-antibody testing, his serum reacted to B. divergens but not to B. microti or WA1 antigens. This case demonstrates that babesiosis can be caused by novel parasites detectable by manual examination of blood smears but not by serologic or molecular testing for B. microti or WA1-type parasites.
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spelling pubmed-33230862012-04-17 Babesia divergens–like Infection, Washington State Herwaldt, Barbara L. de Bruyn, Guy Pieniazek, Norman J. Homer, Mary Lofy, Kathryn H. Slemenda, Susan B. Fritsche, Thomas R. Persing, David H. Limaye, Ajit P. Emerg Infect Dis Research Most reported U.S. zoonotic cases of babesiosis have occurred in the Northeast and been caused by Babesia microti. In Washington State, three cases of babesiosis have been reported previously, which were caused by WA1 (for “Washington 1”)-type parasites. We investigated a case of babesiosis in Washington in an 82–year-old man whose spleen had been removed and whose parasitemia level was 41.4%. The complete 18S ribosomal RNA gene of the parasite was amplified from specimens of his whole blood by polymerase chain reaction. Phylogenetic analysis showed the parasite is most closely related, but not identical, to B. divergens (similarity score, 99.5%), a bovine parasite in Europe. By indirect fluorescent-antibody testing, his serum reacted to B. divergens but not to B. microti or WA1 antigens. This case demonstrates that babesiosis can be caused by novel parasites detectable by manual examination of blood smears but not by serologic or molecular testing for B. microti or WA1-type parasites. Centers for Disease Control and Prevention 2004-04 /pmc/articles/PMC3323086/ /pubmed/15200851 http://dx.doi.org/10.3201/eid1004.030377 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Herwaldt, Barbara L.
de Bruyn, Guy
Pieniazek, Norman J.
Homer, Mary
Lofy, Kathryn H.
Slemenda, Susan B.
Fritsche, Thomas R.
Persing, David H.
Limaye, Ajit P.
Babesia divergens–like Infection, Washington State
title Babesia divergens–like Infection, Washington State
title_full Babesia divergens–like Infection, Washington State
title_fullStr Babesia divergens–like Infection, Washington State
title_full_unstemmed Babesia divergens–like Infection, Washington State
title_short Babesia divergens–like Infection, Washington State
title_sort babesia divergens–like infection, washington state
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323086/
https://www.ncbi.nlm.nih.gov/pubmed/15200851
http://dx.doi.org/10.3201/eid1004.030377
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