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Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East

An acute tick-borne rickettsiosis caused by Rickettsia heilongjiangensis was diagnosed in 13 patients from the Russian Far East in 2002. We amplified and sequenced four portions of three rickettsial genes from the patients’ skin biopsy results and blood samples and showed that the amplified ricketts...

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Autores principales: Mediannikov, Oleg Y., Sidelnikov, Yuri, Ivanov, Leonid, Mokretsova, Eugenia, Fournier, Pierre-Edouard, Tarasevich, Irina, Raoult, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323216/
https://www.ncbi.nlm.nih.gov/pubmed/15200813
http://dx.doi.org/10.3201/eid1005.030437
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author Mediannikov, Oleg Y.
Sidelnikov, Yuri
Ivanov, Leonid
Mokretsova, Eugenia
Fournier, Pierre-Edouard
Tarasevich, Irina
Raoult, Didier
author_facet Mediannikov, Oleg Y.
Sidelnikov, Yuri
Ivanov, Leonid
Mokretsova, Eugenia
Fournier, Pierre-Edouard
Tarasevich, Irina
Raoult, Didier
author_sort Mediannikov, Oleg Y.
collection PubMed
description An acute tick-borne rickettsiosis caused by Rickettsia heilongjiangensis was diagnosed in 13 patients from the Russian Far East in 2002. We amplified and sequenced four portions of three rickettsial genes from the patients’ skin biopsy results and blood samples and showed that the amplified rickettsial genes belong to R. heilongjiangensis, which was recently isolated from Dermacentor sylvarum ticks in nearby regions of China. This rickettsia, belonging to subgroup of R. japonica, was previously suggested to be pathogenic for humans on the basis of serologic findings. We tested serum samples with different rickettsial antigens from 11 patients and confirmed increasing titers of immunoglobulin (Ig) G and IgM to spotted fever group rickettsiae, including R. heilongjiangensis. Clinical and epidemiologic data on these patients shows that this disease is similar to other tick-borne rickettsioses.
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spelling pubmed-33232162012-04-17 Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East Mediannikov, Oleg Y. Sidelnikov, Yuri Ivanov, Leonid Mokretsova, Eugenia Fournier, Pierre-Edouard Tarasevich, Irina Raoult, Didier Emerg Infect Dis Research An acute tick-borne rickettsiosis caused by Rickettsia heilongjiangensis was diagnosed in 13 patients from the Russian Far East in 2002. We amplified and sequenced four portions of three rickettsial genes from the patients’ skin biopsy results and blood samples and showed that the amplified rickettsial genes belong to R. heilongjiangensis, which was recently isolated from Dermacentor sylvarum ticks in nearby regions of China. This rickettsia, belonging to subgroup of R. japonica, was previously suggested to be pathogenic for humans on the basis of serologic findings. We tested serum samples with different rickettsial antigens from 11 patients and confirmed increasing titers of immunoglobulin (Ig) G and IgM to spotted fever group rickettsiae, including R. heilongjiangensis. Clinical and epidemiologic data on these patients shows that this disease is similar to other tick-borne rickettsioses. Centers for Disease Control and Prevention 2004-05 /pmc/articles/PMC3323216/ /pubmed/15200813 http://dx.doi.org/10.3201/eid1005.030437 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Mediannikov, Oleg Y.
Sidelnikov, Yuri
Ivanov, Leonid
Mokretsova, Eugenia
Fournier, Pierre-Edouard
Tarasevich, Irina
Raoult, Didier
Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East
title Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East
title_full Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East
title_fullStr Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East
title_full_unstemmed Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East
title_short Acute Tick-borne Rickettsiosis Caused by Rickettsia sibirica in the Russian Far East
title_sort acute tick-borne rickettsiosis caused by rickettsia sibirica in the russian far east
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323216/
https://www.ncbi.nlm.nih.gov/pubmed/15200813
http://dx.doi.org/10.3201/eid1005.030437
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