Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif sugge...

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Autores principales: Beasley, David W.C., Davis, C. Todd, Estrada-Franco, Jose, Navarro-Lopez, Roberto, Campomanes-Cortes, Arturo, Tesh, Robert B., Weaver, Scott C., Barrett, Alan D.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2004
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323401/
https://www.ncbi.nlm.nih.gov/pubmed/15663867
http://dx.doi.org/10.3201/eid1012.040647
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author Beasley, David W.C.
Davis, C. Todd
Estrada-Franco, Jose
Navarro-Lopez, Roberto
Campomanes-Cortes, Arturo
Tesh, Robert B.
Weaver, Scott C.
Barrett, Alan D.T.
author_facet Beasley, David W.C.
Davis, C. Todd
Estrada-Franco, Jose
Navarro-Lopez, Roberto
Campomanes-Cortes, Arturo
Tesh, Robert B.
Weaver, Scott C.
Barrett, Alan D.T.
author_sort Beasley, David W.C.
collection PubMed
description The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
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spelling pubmed-33234012012-04-18 Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico Beasley, David W.C. Davis, C. Todd Estrada-Franco, Jose Navarro-Lopez, Roberto Campomanes-Cortes, Arturo Tesh, Robert B. Weaver, Scott C. Barrett, Alan D.T. Emerg Infect Dis Dispatch The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation. Centers for Disease Control and Prevention 2004-12 /pmc/articles/PMC3323401/ /pubmed/15663867 http://dx.doi.org/10.3201/eid1012.040647 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Beasley, David W.C.
Davis, C. Todd
Estrada-Franco, Jose
Navarro-Lopez, Roberto
Campomanes-Cortes, Arturo
Tesh, Robert B.
Weaver, Scott C.
Barrett, Alan D.T.
Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
title Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
title_full Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
title_fullStr Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
title_full_unstemmed Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
title_short Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
title_sort genome sequence and attenuating mutations in west nile virus isolate from mexico
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323401/
https://www.ncbi.nlm.nih.gov/pubmed/15663867
http://dx.doi.org/10.3201/eid1012.040647
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