Age-Related Skeletal Dynamics and Decrease in Bone Strength in DNA Repair Deficient Male Trichothiodystrophy Mice

Accumulation of DNA damage caused by oxidative stress is thought to be one of the main contributors of human tissue aging. Trichothiodystrophy (TTD) mice have a mutation in the Ercc2 DNA repair gene, resulting in accumulation of DNA damage and several features of segmental accelerated aging. We used...

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Detalles Bibliográficos
Autores principales: Nicolaije, Claudia, Diderich, Karin E. M., Botter, S. M., Priemel, Matthias, Waarsing, Jan H., Day, Judd S., Brandt, Renata M. C., Schilling, Arndt F., Weinans, Harrie, Van der Eerden, Bram C., van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., van Leeuwen, Johannes P. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323647/
https://www.ncbi.nlm.nih.gov/pubmed/22506075
http://dx.doi.org/10.1371/journal.pone.0035246

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