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Different dimerisation mode for TLR4 upon endosomal acidification?
TLR4 is unique among pathogen-recognition receptors in that it initiates different pathways in different cellular locations. Binding of a bridging factor, Mal, allows recruitment of an adapter protein, MyD88, at the plasma membrane, which leads to the production of proinflammatory cytokines. Upon in...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Trends Journals
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323831/ https://www.ncbi.nlm.nih.gov/pubmed/22196451 http://dx.doi.org/10.1016/j.tibs.2011.11.003 |