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A Possible Mechanism of Renal Cell Death after Ischemia/reperfusion
In this issue of Kidney International, Linkermann, et al. provide the first evidence for a possible biochemical mechanism of necrotic kidney cell death associated with renal ischemia/reperfusion-induced acute kidney injury. The mechanisms of several pathways resulting in programmed necrosis were rec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324283/ https://www.ncbi.nlm.nih.gov/pubmed/22460652 http://dx.doi.org/10.1038/ki.2011.495 |
Sumario: | In this issue of Kidney International, Linkermann, et al. provide the first evidence for a possible biochemical mechanism of necrotic kidney cell death associated with renal ischemia/reperfusion-induced acute kidney injury. The mechanisms of several pathways resulting in programmed necrosis were recently elucidated and rely on receptor-interacting protein kinases 1 and 3. Using an inhibitor of one of these kinases, Linkermann was able to ameliorate functional and morphologic kidney damage after ischemia/reperfusion. |
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