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Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis
BACKGROUND: We analyzed the causal relationship between LDL susceptibility to oxidation and the development of new carotid artery atherosclerosis over a period of 5 years. We previously described the determinants related to a risk of cardiovascular changes determined in a Japanese population partici...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324386/ https://www.ncbi.nlm.nih.gov/pubmed/22230558 http://dx.doi.org/10.1186/1476-511X-11-4 |
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author | Aoki, Toshinari Abe, Tsueko Yamada, Eiji Matsuto, Takayuki Okada, Masahiko |
author_facet | Aoki, Toshinari Abe, Tsueko Yamada, Eiji Matsuto, Takayuki Okada, Masahiko |
author_sort | Aoki, Toshinari |
collection | PubMed |
description | BACKGROUND: We analyzed the causal relationship between LDL susceptibility to oxidation and the development of new carotid artery atherosclerosis over a period of 5 years. We previously described the determinants related to a risk of cardiovascular changes determined in a Japanese population participating in the Niigata Study, which is an ongoing epidemiological investigation of the prevention of cardiovascular diseases. METHODS: We selected 394 individuals (169 males and 225 females) who underwent a second carotid artery ultrasonographic examination in 2001 - 2002 for the present study. The susceptibility of LDL to oxidation was determined as the photometric absorbance and electrophoretic mobility of samples that had been collected in 1996 - 1997. The measurements were compared with ultrasonographic findings obtained in 2001 - 2002. RESULTS: The multivariate-adjusted model showed that age (odds ratio (OR), 1.034; 95% confidence interval (95%CI), 1.010 - 1.059), HbA1c (OR, 1.477; 95%CI, 0.980 - 2.225), and photometric O/N (OR, 2.012; 95%CI, 1.000 - 4.051) were significant variables that could independently predict the risk of new carotid artery atherosclerosis. CONCLUSION: The susceptibility of LDL to oxidation was a significant parameter that could predict new carotid artery atherosclerosis over a 5-year period, and higher susceptibility was associated with a higher incidence of new carotid artery atherosclerosis. |
format | Online Article Text |
id | pubmed-3324386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33243862012-04-12 Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis Aoki, Toshinari Abe, Tsueko Yamada, Eiji Matsuto, Takayuki Okada, Masahiko Lipids Health Dis Research BACKGROUND: We analyzed the causal relationship between LDL susceptibility to oxidation and the development of new carotid artery atherosclerosis over a period of 5 years. We previously described the determinants related to a risk of cardiovascular changes determined in a Japanese population participating in the Niigata Study, which is an ongoing epidemiological investigation of the prevention of cardiovascular diseases. METHODS: We selected 394 individuals (169 males and 225 females) who underwent a second carotid artery ultrasonographic examination in 2001 - 2002 for the present study. The susceptibility of LDL to oxidation was determined as the photometric absorbance and electrophoretic mobility of samples that had been collected in 1996 - 1997. The measurements were compared with ultrasonographic findings obtained in 2001 - 2002. RESULTS: The multivariate-adjusted model showed that age (odds ratio (OR), 1.034; 95% confidence interval (95%CI), 1.010 - 1.059), HbA1c (OR, 1.477; 95%CI, 0.980 - 2.225), and photometric O/N (OR, 2.012; 95%CI, 1.000 - 4.051) were significant variables that could independently predict the risk of new carotid artery atherosclerosis. CONCLUSION: The susceptibility of LDL to oxidation was a significant parameter that could predict new carotid artery atherosclerosis over a 5-year period, and higher susceptibility was associated with a higher incidence of new carotid artery atherosclerosis. BioMed Central 2012-01-09 /pmc/articles/PMC3324386/ /pubmed/22230558 http://dx.doi.org/10.1186/1476-511X-11-4 Text en Copyright ©2012 Aoki et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Aoki, Toshinari Abe, Tsueko Yamada, Eiji Matsuto, Takayuki Okada, Masahiko Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis |
title | Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis |
title_full | Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis |
title_fullStr | Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis |
title_full_unstemmed | Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis |
title_short | Increased LDL susceptibility to oxidation accelerates future carotid artery atherosclerosis |
title_sort | increased ldl susceptibility to oxidation accelerates future carotid artery atherosclerosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324386/ https://www.ncbi.nlm.nih.gov/pubmed/22230558 http://dx.doi.org/10.1186/1476-511X-11-4 |
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