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Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study

BACKGROUND: Exposure to air pollutants is suggested to adversely affect fetal growth, but the evidence remains inconsistent in relation to specific outcomes and exposure windows. METHODS: Using birth records from the two major maternity hospitals in Newcastle upon Tyne in northern England between 19...

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Autores principales: Pearce, Mark S, Glinianaia, Svetlana V, Ghosh, Rakesh, Rankin, Judith, Rushton, Steven, Charlton, Martin, Parker, Louise, Pless-Mulloli, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324390/
https://www.ncbi.nlm.nih.gov/pubmed/22404858
http://dx.doi.org/10.1186/1476-069X-11-13
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author Pearce, Mark S
Glinianaia, Svetlana V
Ghosh, Rakesh
Rankin, Judith
Rushton, Steven
Charlton, Martin
Parker, Louise
Pless-Mulloli, Tanja
author_facet Pearce, Mark S
Glinianaia, Svetlana V
Ghosh, Rakesh
Rankin, Judith
Rushton, Steven
Charlton, Martin
Parker, Louise
Pless-Mulloli, Tanja
author_sort Pearce, Mark S
collection PubMed
description BACKGROUND: Exposure to air pollutants is suggested to adversely affect fetal growth, but the evidence remains inconsistent in relation to specific outcomes and exposure windows. METHODS: Using birth records from the two major maternity hospitals in Newcastle upon Tyne in northern England between 1961 and 1992, we constructed a database of all births to mothers resident within the city. Weekly black smoke exposure levels from routine data recorded at 20 air pollution monitoring stations were obtained and individual exposures were estimated via a two-stage modeling strategy, incorporating temporally and spatially varying covariates. Regression analyses, including 88,679 births, assessed potential associations between exposure to black smoke and birth weight, gestational age and birth weight standardized for gestational age and sex. RESULTS: Significant associations were seen between black smoke and both standardized and unstandardized birth weight, but not for gestational age when adjusted for potential confounders. Not all associations were linear. For an increase in whole pregnancy black smoke exposure, from the 1(st )(7.4 μg/m(3)) to the 25(th )(17.2 μg/m(3)), 50(th )(33.8 μg/m(3)), 75(th )(108.3 μg/m(3)), and 90(th )(180.8 μg/m(3)) percentiles, the adjusted estimated decreases in birth weight were 33 g (SE 1.05), 62 g (1.63), 98 g (2.26) and 109 g (2.44) respectively. A significant interaction was observed between socio-economic deprivation and black smoke on both standardized and unstandardized birth weight with increasing effects of black smoke in reducing birth weight seen with increasing socio-economic disadvantage. CONCLUSIONS: The findings of this study progress the hypothesis that the association between black smoke and birth weight may be mediated through intrauterine growth restriction. The associations between black smoke and birth weight were of the same order of magnitude as those reported for passive smoking. These findings add to the growing evidence of the harmful effects of air pollution on birth outcomes.
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spelling pubmed-33243902012-04-12 Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study Pearce, Mark S Glinianaia, Svetlana V Ghosh, Rakesh Rankin, Judith Rushton, Steven Charlton, Martin Parker, Louise Pless-Mulloli, Tanja Environ Health Research BACKGROUND: Exposure to air pollutants is suggested to adversely affect fetal growth, but the evidence remains inconsistent in relation to specific outcomes and exposure windows. METHODS: Using birth records from the two major maternity hospitals in Newcastle upon Tyne in northern England between 1961 and 1992, we constructed a database of all births to mothers resident within the city. Weekly black smoke exposure levels from routine data recorded at 20 air pollution monitoring stations were obtained and individual exposures were estimated via a two-stage modeling strategy, incorporating temporally and spatially varying covariates. Regression analyses, including 88,679 births, assessed potential associations between exposure to black smoke and birth weight, gestational age and birth weight standardized for gestational age and sex. RESULTS: Significant associations were seen between black smoke and both standardized and unstandardized birth weight, but not for gestational age when adjusted for potential confounders. Not all associations were linear. For an increase in whole pregnancy black smoke exposure, from the 1(st )(7.4 μg/m(3)) to the 25(th )(17.2 μg/m(3)), 50(th )(33.8 μg/m(3)), 75(th )(108.3 μg/m(3)), and 90(th )(180.8 μg/m(3)) percentiles, the adjusted estimated decreases in birth weight were 33 g (SE 1.05), 62 g (1.63), 98 g (2.26) and 109 g (2.44) respectively. A significant interaction was observed between socio-economic deprivation and black smoke on both standardized and unstandardized birth weight with increasing effects of black smoke in reducing birth weight seen with increasing socio-economic disadvantage. CONCLUSIONS: The findings of this study progress the hypothesis that the association between black smoke and birth weight may be mediated through intrauterine growth restriction. The associations between black smoke and birth weight were of the same order of magnitude as those reported for passive smoking. These findings add to the growing evidence of the harmful effects of air pollution on birth outcomes. BioMed Central 2012-03-09 /pmc/articles/PMC3324390/ /pubmed/22404858 http://dx.doi.org/10.1186/1476-069X-11-13 Text en Copyright ©2012 Pearce et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Pearce, Mark S
Glinianaia, Svetlana V
Ghosh, Rakesh
Rankin, Judith
Rushton, Steven
Charlton, Martin
Parker, Louise
Pless-Mulloli, Tanja
Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
title Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
title_full Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
title_fullStr Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
title_full_unstemmed Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
title_short Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
title_sort particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324390/
https://www.ncbi.nlm.nih.gov/pubmed/22404858
http://dx.doi.org/10.1186/1476-069X-11-13
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