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Prostate Cancer-Specific and Potent Antitumor Effect of a DD3-Controlled Oncolytic Virus Harboring the PTEN Gene

Prostate cancer is a major health problem for men in Western societies. Here we report a Prostate Cancer-Specific Targeting Gene-Viro-Therapy (CTGVT-PCa), in which PTEN was inserted into a DD3-controlled oncolytic viral vector (OV) to form Ad.DD3.E1A.E1B(Δ55)-(PTEN) or, briefly, Ad.DD3.D55-PTEN. The...

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Detalles Bibliográficos
Autores principales:	Ding, Miao, Cao, Xin, Xu, Hai-neng, Fan, Jun-kai, Huang, Hong-ling, Yang, Dong-qin, Li, Yu-hua, Wang, Jian, Li, Runsheng, Liu, Xin-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324420/ https://www.ncbi.nlm.nih.gov/pubmed/22509396 http://dx.doi.org/10.1371/journal.pone.0035153

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