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PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies

Vaccines based on microbial cell surface polysaccharides have long been considered as attractive means to control infectious diseases. To realize this goal, detailed systematic information about the antigenic polysaccharide is necessary. However, only a few databases that provide limited knowledge i...

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Detalles Bibliográficos
Autores principales: Aithal, Abhijit, Sharma, Arun, Joshi, Shilpy, Raghava, Gajendra P. S., Varshney, Grish C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324500/
https://www.ncbi.nlm.nih.gov/pubmed/22509333
http://dx.doi.org/10.1371/journal.pone.0034613
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author Aithal, Abhijit
Sharma, Arun
Joshi, Shilpy
Raghava, Gajendra P. S.
Varshney, Grish C.
author_facet Aithal, Abhijit
Sharma, Arun
Joshi, Shilpy
Raghava, Gajendra P. S.
Varshney, Grish C.
author_sort Aithal, Abhijit
collection PubMed
description Vaccines based on microbial cell surface polysaccharides have long been considered as attractive means to control infectious diseases. To realize this goal, detailed systematic information about the antigenic polysaccharide is necessary. However, only a few databases that provide limited knowledge in this area are available. This paper describes PolysacDB, a manually curated database of antigenic polysaccharides. We collected and compiled comprehensive information from literature and web resources about antigenic polysaccharides of microbial origin. The current version of the database has 1,554 entries of 149 different antigenic polysaccharides from 347 different microbes. Each entry provides comprehensive information about an antigenic polysaccharide, i.e., its origin, function, protocols for its conjugation to carriers, antibodies produced, details of assay systems, specificities of antibodies, proposed epitopes involved and antibody utilities. For convenience to the user, we have integrated web interface for searching, advanced searching and browsing data in database. This database will be useful for researchers working on polysaccharide-based vaccines. It is freely available from the URL: http://crdd.osdd.net/raghava/polysacdb/.
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spelling pubmed-33245002012-04-16 PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies Aithal, Abhijit Sharma, Arun Joshi, Shilpy Raghava, Gajendra P. S. Varshney, Grish C. PLoS One Research Article Vaccines based on microbial cell surface polysaccharides have long been considered as attractive means to control infectious diseases. To realize this goal, detailed systematic information about the antigenic polysaccharide is necessary. However, only a few databases that provide limited knowledge in this area are available. This paper describes PolysacDB, a manually curated database of antigenic polysaccharides. We collected and compiled comprehensive information from literature and web resources about antigenic polysaccharides of microbial origin. The current version of the database has 1,554 entries of 149 different antigenic polysaccharides from 347 different microbes. Each entry provides comprehensive information about an antigenic polysaccharide, i.e., its origin, function, protocols for its conjugation to carriers, antibodies produced, details of assay systems, specificities of antibodies, proposed epitopes involved and antibody utilities. For convenience to the user, we have integrated web interface for searching, advanced searching and browsing data in database. This database will be useful for researchers working on polysaccharide-based vaccines. It is freely available from the URL: http://crdd.osdd.net/raghava/polysacdb/. Public Library of Science 2012-04-11 /pmc/articles/PMC3324500/ /pubmed/22509333 http://dx.doi.org/10.1371/journal.pone.0034613 Text en Aithal et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Aithal, Abhijit
Sharma, Arun
Joshi, Shilpy
Raghava, Gajendra P. S.
Varshney, Grish C.
PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies
title PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies
title_full PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies
title_fullStr PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies
title_full_unstemmed PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies
title_short PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies
title_sort polysacdb: a database of microbial polysaccharide antigens and their antibodies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324500/
https://www.ncbi.nlm.nih.gov/pubmed/22509333
http://dx.doi.org/10.1371/journal.pone.0034613
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