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Altering an Artificial Gagpolnef Polyprotein and Mode of ENV Co-Administration Affects the Immunogenicity of a Clade C HIV DNA Vaccine

HIV-1 candidate vaccines expressing an artificial polyprotein comprising Gag, Pol and Nef (GPN) and a secreted envelope protein (Env) were shown in recent Phase I/II clinical trials to induce high levels of polyfunctional T cell responses; however, Env-specific responses clearly exceeded those again...

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Detalles Bibliográficos
Autores principales:	Böckl, Katharina, Wild, Jens, Bredl, Simon, Kindsmüller, Kathrin, Köstler, Josef, Wagner, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324526/ https://www.ncbi.nlm.nih.gov/pubmed/22509350 http://dx.doi.org/10.1371/journal.pone.0034723

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