Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats

Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Methionine aminopeptidase-2 (MetAP2) regulat...

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Detalles Bibliográficos
Autores principales: Kass, Daniel J., Rattigan, Eileen, Kahloon, Rehan, Loh, Katrina, Yu, Liyang, Savir, Asaf, Markowski, Mark, Saqi, Anjali, Rajkumar, Revathi, Ahmad, Ferhaan, Champion, Hunter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324555/
https://www.ncbi.nlm.nih.gov/pubmed/22509410
http://dx.doi.org/10.1371/journal.pone.0035388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324555/
https://www.ncbi.nlm.nih.gov/pubmed/22509410
http://dx.doi.org/10.1371/journal.pone.0035388

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