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Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats
Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Methionine aminopeptidase-2 (MetAP2) regulat...
Autores principales: | Kass, Daniel J., Rattigan, Eileen, Kahloon, Rehan, Loh, Katrina, Yu, Liyang, Savir, Asaf, Markowski, Mark, Saqi, Anjali, Rajkumar, Revathi, Ahmad, Ferhaan, Champion, Hunter C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324555/ https://www.ncbi.nlm.nih.gov/pubmed/22509410 http://dx.doi.org/10.1371/journal.pone.0035388 |
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