Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)

Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Di...

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Detalles Bibliográficos
Autores principales: Staal, Wouter G., de Krom, Mariken, de Jonge, Maretha V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324694/
https://www.ncbi.nlm.nih.gov/pubmed/21691864
http://dx.doi.org/10.1007/s10803-011-1312-z
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author Staal, Wouter G.
de Krom, Mariken
de Jonge, Maretha V.
author_facet Staal, Wouter G.
de Krom, Mariken
de Jonge, Maretha V.
author_sort Staal, Wouter G.
collection PubMed
description Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing.
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spelling pubmed-33246942012-04-20 Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) Staal, Wouter G. de Krom, Mariken de Jonge, Maretha V. J Autism Dev Disord Brief Report Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor “insistence on sameness” (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind that these results would not be statistically significant if corrected for multiple testing. Springer US 2011-06-21 2012 /pmc/articles/PMC3324694/ /pubmed/21691864 http://dx.doi.org/10.1007/s10803-011-1312-z Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Brief Report
Staal, Wouter G.
de Krom, Mariken
de Jonge, Maretha V.
Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
title Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
title_full Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
title_fullStr Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
title_full_unstemmed Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
title_short Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD)
title_sort brief report: the dopamine-3-receptor gene (drd3) is associated with specific repetitive behavior in autism spectrum disorder (asd)
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324694/
https://www.ncbi.nlm.nih.gov/pubmed/21691864
http://dx.doi.org/10.1007/s10803-011-1312-z
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