Cargando…

Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients

The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhartiya, Deepa, Sriraman, Kalpana, Parte, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324916/
https://www.ncbi.nlm.nih.gov/pubmed/22548074
http://dx.doi.org/10.1155/2012/921082
_version_ 1782229364425883648
author Bhartiya, Deepa
Sriraman, Kalpana
Parte, Seema
author_facet Bhartiya, Deepa
Sriraman, Kalpana
Parte, Seema
author_sort Bhartiya, Deepa
collection PubMed
description The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options.
format Online
Article
Text
id pubmed-3324916
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33249162012-04-30 Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients Bhartiya, Deepa Sriraman, Kalpana Parte, Seema Obstet Gynecol Int Review Article The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options. Hindawi Publishing Corporation 2012 2012-04-02 /pmc/articles/PMC3324916/ /pubmed/22548074 http://dx.doi.org/10.1155/2012/921082 Text en Copyright © 2012 Deepa Bhartiya et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bhartiya, Deepa
Sriraman, Kalpana
Parte, Seema
Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
title Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
title_full Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
title_fullStr Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
title_full_unstemmed Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
title_short Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
title_sort stem cell interaction with somatic niche may hold the key to fertility restoration in cancer patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324916/
https://www.ncbi.nlm.nih.gov/pubmed/22548074
http://dx.doi.org/10.1155/2012/921082
work_keys_str_mv AT bhartiyadeepa stemcellinteractionwithsomaticnichemayholdthekeytofertilityrestorationincancerpatients
AT sriramankalpana stemcellinteractionwithsomaticnichemayholdthekeytofertilityrestorationincancerpatients
AT parteseema stemcellinteractionwithsomaticnichemayholdthekeytofertilityrestorationincancerpatients