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Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324916/ https://www.ncbi.nlm.nih.gov/pubmed/22548074 http://dx.doi.org/10.1155/2012/921082 |
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author | Bhartiya, Deepa Sriraman, Kalpana Parte, Seema |
author_facet | Bhartiya, Deepa Sriraman, Kalpana Parte, Seema |
author_sort | Bhartiya, Deepa |
collection | PubMed |
description | The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options. |
format | Online Article Text |
id | pubmed-3324916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33249162012-04-30 Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients Bhartiya, Deepa Sriraman, Kalpana Parte, Seema Obstet Gynecol Int Review Article The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options. Hindawi Publishing Corporation 2012 2012-04-02 /pmc/articles/PMC3324916/ /pubmed/22548074 http://dx.doi.org/10.1155/2012/921082 Text en Copyright © 2012 Deepa Bhartiya et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bhartiya, Deepa Sriraman, Kalpana Parte, Seema Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
title | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
title_full | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
title_fullStr | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
title_full_unstemmed | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
title_short | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
title_sort | stem cell interaction with somatic niche may hold the key to fertility restoration in cancer patients |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324916/ https://www.ncbi.nlm.nih.gov/pubmed/22548074 http://dx.doi.org/10.1155/2012/921082 |
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