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Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning

Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by whi...

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Autores principales: Rosenberg-Katz, Keren, Jamshy, Shahar, Singer, Neomi, Podlipsky, Ilana, Kipervasser, Svetlana, Andelman, Fani, Neufeld, Miri Y., Intrator, Nathan, Fried, Itzhak, Hendler, Talma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324921/
https://www.ncbi.nlm.nih.gov/pubmed/22518101
http://dx.doi.org/10.3389/fnhum.2012.00079
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author Rosenberg-Katz, Keren
Jamshy, Shahar
Singer, Neomi
Podlipsky, Ilana
Kipervasser, Svetlana
Andelman, Fani
Neufeld, Miri Y.
Intrator, Nathan
Fried, Itzhak
Hendler, Talma
author_facet Rosenberg-Katz, Keren
Jamshy, Shahar
Singer, Neomi
Podlipsky, Ilana
Kipervasser, Svetlana
Andelman, Fani
Neufeld, Miri Y.
Intrator, Nathan
Fried, Itzhak
Hendler, Talma
author_sort Rosenberg-Katz, Keren
collection PubMed
description Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by which this area interacts with other cognitive brain regions such as the dorsolateral prefrontal cortex, a central node in decision-making, is still unclear. To shed light on this mechanism, brain activity was measured via fMRI and intracranial EEG in two studies during the performance of visually cued repeated finger tapping in which the choice of finger was guided by either a presented number (external) or self-choice (internal). A functional-MRI (fMRI) study in 15 healthy participants demonstrated that the pre-SMA, compared to the SMA proper, was more active and also more functionally correlated with the dorsolateral prefrontal cortex during internally compared to externally guided action planning (p < 0.05, random effect). In a similar manner, an intracranial-EEG study in five epilepsy patients showed greater inter-regional gamma-related connectivity between electrodes situated in medial and lateral aspects of the prefrontal cortex for internally compared to externally guided actions. Although this finding was observed for groups of electrodes situated both in the pre-SMA and SMA-proper, increased intra-cluster gamma-related connectivity was only observed for the pre-SMA (sign-test, p < 0.0001). Overall our findings provide multi-scale indications for the involvement of the dorsomedial prefrontal cortex, and especially the pre-SMA, in generating internally guided motor planning. Our intracranial-EEG results further point to enhanced functional connectivity between decision-making- and motor planning aspects of the PFC, as a possible neural mechanism for internally generated action planning.
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spelling pubmed-33249212012-04-19 Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning Rosenberg-Katz, Keren Jamshy, Shahar Singer, Neomi Podlipsky, Ilana Kipervasser, Svetlana Andelman, Fani Neufeld, Miri Y. Intrator, Nathan Fried, Itzhak Hendler, Talma Front Hum Neurosci Neuroscience Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by which this area interacts with other cognitive brain regions such as the dorsolateral prefrontal cortex, a central node in decision-making, is still unclear. To shed light on this mechanism, brain activity was measured via fMRI and intracranial EEG in two studies during the performance of visually cued repeated finger tapping in which the choice of finger was guided by either a presented number (external) or self-choice (internal). A functional-MRI (fMRI) study in 15 healthy participants demonstrated that the pre-SMA, compared to the SMA proper, was more active and also more functionally correlated with the dorsolateral prefrontal cortex during internally compared to externally guided action planning (p < 0.05, random effect). In a similar manner, an intracranial-EEG study in five epilepsy patients showed greater inter-regional gamma-related connectivity between electrodes situated in medial and lateral aspects of the prefrontal cortex for internally compared to externally guided actions. Although this finding was observed for groups of electrodes situated both in the pre-SMA and SMA-proper, increased intra-cluster gamma-related connectivity was only observed for the pre-SMA (sign-test, p < 0.0001). Overall our findings provide multi-scale indications for the involvement of the dorsomedial prefrontal cortex, and especially the pre-SMA, in generating internally guided motor planning. Our intracranial-EEG results further point to enhanced functional connectivity between decision-making- and motor planning aspects of the PFC, as a possible neural mechanism for internally generated action planning. Frontiers Media S.A. 2012-04-12 /pmc/articles/PMC3324921/ /pubmed/22518101 http://dx.doi.org/10.3389/fnhum.2012.00079 Text en Copyright © 2012 Rosenberg-Katz, Jamshy, Singer, Podlipsky, Kipervasser, Andelman, Neufeld, Intrator, Fried and Hendler. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Rosenberg-Katz, Keren
Jamshy, Shahar
Singer, Neomi
Podlipsky, Ilana
Kipervasser, Svetlana
Andelman, Fani
Neufeld, Miri Y.
Intrator, Nathan
Fried, Itzhak
Hendler, Talma
Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
title Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
title_full Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
title_fullStr Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
title_full_unstemmed Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
title_short Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
title_sort enhanced functional synchronization of medial and lateral pfc underlies internally-guided action planning
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324921/
https://www.ncbi.nlm.nih.gov/pubmed/22518101
http://dx.doi.org/10.3389/fnhum.2012.00079
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