Cargando…
Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by whi...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324921/ https://www.ncbi.nlm.nih.gov/pubmed/22518101 http://dx.doi.org/10.3389/fnhum.2012.00079 |
_version_ | 1782229365573025792 |
---|---|
author | Rosenberg-Katz, Keren Jamshy, Shahar Singer, Neomi Podlipsky, Ilana Kipervasser, Svetlana Andelman, Fani Neufeld, Miri Y. Intrator, Nathan Fried, Itzhak Hendler, Talma |
author_facet | Rosenberg-Katz, Keren Jamshy, Shahar Singer, Neomi Podlipsky, Ilana Kipervasser, Svetlana Andelman, Fani Neufeld, Miri Y. Intrator, Nathan Fried, Itzhak Hendler, Talma |
author_sort | Rosenberg-Katz, Keren |
collection | PubMed |
description | Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by which this area interacts with other cognitive brain regions such as the dorsolateral prefrontal cortex, a central node in decision-making, is still unclear. To shed light on this mechanism, brain activity was measured via fMRI and intracranial EEG in two studies during the performance of visually cued repeated finger tapping in which the choice of finger was guided by either a presented number (external) or self-choice (internal). A functional-MRI (fMRI) study in 15 healthy participants demonstrated that the pre-SMA, compared to the SMA proper, was more active and also more functionally correlated with the dorsolateral prefrontal cortex during internally compared to externally guided action planning (p < 0.05, random effect). In a similar manner, an intracranial-EEG study in five epilepsy patients showed greater inter-regional gamma-related connectivity between electrodes situated in medial and lateral aspects of the prefrontal cortex for internally compared to externally guided actions. Although this finding was observed for groups of electrodes situated both in the pre-SMA and SMA-proper, increased intra-cluster gamma-related connectivity was only observed for the pre-SMA (sign-test, p < 0.0001). Overall our findings provide multi-scale indications for the involvement of the dorsomedial prefrontal cortex, and especially the pre-SMA, in generating internally guided motor planning. Our intracranial-EEG results further point to enhanced functional connectivity between decision-making- and motor planning aspects of the PFC, as a possible neural mechanism for internally generated action planning. |
format | Online Article Text |
id | pubmed-3324921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-33249212012-04-19 Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning Rosenberg-Katz, Keren Jamshy, Shahar Singer, Neomi Podlipsky, Ilana Kipervasser, Svetlana Andelman, Fani Neufeld, Miri Y. Intrator, Nathan Fried, Itzhak Hendler, Talma Front Hum Neurosci Neuroscience Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by which this area interacts with other cognitive brain regions such as the dorsolateral prefrontal cortex, a central node in decision-making, is still unclear. To shed light on this mechanism, brain activity was measured via fMRI and intracranial EEG in two studies during the performance of visually cued repeated finger tapping in which the choice of finger was guided by either a presented number (external) or self-choice (internal). A functional-MRI (fMRI) study in 15 healthy participants demonstrated that the pre-SMA, compared to the SMA proper, was more active and also more functionally correlated with the dorsolateral prefrontal cortex during internally compared to externally guided action planning (p < 0.05, random effect). In a similar manner, an intracranial-EEG study in five epilepsy patients showed greater inter-regional gamma-related connectivity between electrodes situated in medial and lateral aspects of the prefrontal cortex for internally compared to externally guided actions. Although this finding was observed for groups of electrodes situated both in the pre-SMA and SMA-proper, increased intra-cluster gamma-related connectivity was only observed for the pre-SMA (sign-test, p < 0.0001). Overall our findings provide multi-scale indications for the involvement of the dorsomedial prefrontal cortex, and especially the pre-SMA, in generating internally guided motor planning. Our intracranial-EEG results further point to enhanced functional connectivity between decision-making- and motor planning aspects of the PFC, as a possible neural mechanism for internally generated action planning. Frontiers Media S.A. 2012-04-12 /pmc/articles/PMC3324921/ /pubmed/22518101 http://dx.doi.org/10.3389/fnhum.2012.00079 Text en Copyright © 2012 Rosenberg-Katz, Jamshy, Singer, Podlipsky, Kipervasser, Andelman, Neufeld, Intrator, Fried and Hendler. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Neuroscience Rosenberg-Katz, Keren Jamshy, Shahar Singer, Neomi Podlipsky, Ilana Kipervasser, Svetlana Andelman, Fani Neufeld, Miri Y. Intrator, Nathan Fried, Itzhak Hendler, Talma Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
title | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
title_full | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
title_fullStr | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
title_full_unstemmed | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
title_short | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
title_sort | enhanced functional synchronization of medial and lateral pfc underlies internally-guided action planning |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324921/ https://www.ncbi.nlm.nih.gov/pubmed/22518101 http://dx.doi.org/10.3389/fnhum.2012.00079 |
work_keys_str_mv | AT rosenbergkatzkeren enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT jamshyshahar enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT singerneomi enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT podlipskyilana enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT kipervassersvetlana enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT andelmanfani enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT neufeldmiriy enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT intratornathan enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT frieditzhak enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning AT hendlertalma enhancedfunctionalsynchronizationofmedialandlateralpfcunderliesinternallyguidedactionplanning |